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Parallel, automated synthesis with online / offline NMR

ISYNTH for library synthesis and reaction screening with online/offline NMR
High-throughput library synthesis and reaction screening with online benchtop NMR (e.g. automated synthesis, online characterization, data analysis, AI / ML closed loop).

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our various reactor formats for conventional, MW-assisted, reactive gas, photochem synthesis and our user-friendly software enable you to accelerate, standardize, digitalize your library synthesis and reaction screening workflows.
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Overview

Chemspeed's solution

Molecules discovery (e.g. in medicinal chemistry) is driven more and more by the demand for innovative medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same resources. 

Chemspeed’s fully automated, integrated ISYNTH stands for a flexible, modular, and uncompromising automated solution that:

Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the reaction space, reagent space and molecule space.

Chemspeed’s ISYNTH deck modularity provides unrivalled versatility to execute and perform a variety of synthesis workflows (conventional, MW-assisted, photochem, reactive gas) in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.

Enhances your efficiency and productivity by a factor of up to 100 in, for example: C-C / C-N coupling reactions, organometallic reactions (e.g. Grignard), alkylations, Diels-Alder reactions and transfer hydrogenations.

Workflow

Example workflow

The interactive workflow panel below showcases example workflows for this solution. Each Chemspeed tool or module performs a set of specific actions, as in any manual lab workflow, and an almost limitless arrangement of these tools is possible.

ISYNTH with integrated online / offline NMR

Details
đź’ˇ Click on a workflow node to see more details in this details panel.
Benefits

Powerful advantages

  • Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis as well as reaction screening.
  • Easy-to-use disposable multi-functional, high-precision glass reactor arrays, available reaction scales from μL to mL.
  • Glass reactor arrays with screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C / -70°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
  • Proprietary robotic tool exchange.
  • Gravimetric solid handling from μg to g.
  • Gravimetric liquid handling from mg to g / μL to mL.
  • Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
  • Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
  • Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
  • Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry (optional integration within customized MBraun glove-box).
  • Integrated online benchtop NMR with available operating frequency ranges of e.g. 80 / 90 MHz such as Bruker Fourier Rxn Lite, Magritek Spinsolve.
    • NMR device
    • Sample injection port, software and hardware integration
    • H, F, C, P, Si, B
    • 1D and 2D spectra
    • online data acquisition via flow cell or offline via standard 5 mm sample tubes
    • permanent magnet - no liquid nitrogen or helium required
    • 2 Gauss line inside NMR device housing.
Software

AUTOSUITE

Chemspeed’s AUTOSUITE software packages execute and control all modules in every solution. They control all Chemspeed robotic platforms and any other integrated 3rd-party software and hardware.

Explore AUTOSUITE
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Automate and digitalize your laboratory with Chemspeed.