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versatile solid reagent filling into a vast range of recipients enabled by our unique overhead gravimetric dispensing of solids and automated decapping / capping.","versatile-solid-reagent-filling","Versatile solid reagent filling",{"id":583,"title":584,"description":585,"permalink":586,"name":573,"platform":564,"platform_image":587,"categories":47},256,"SWING POWDERDOSE","Automated gravimetric solid dispensing / dosing - precision, accuracy, speed, data integrity (incl. applications in GMP environments).","automated-precision-solid-dispensing","dbda3962-1808-41d6-bdb8-837601159ae6",{"id":589,"title":590,"description":591,"permalink":592,"name":593,"platform":574,"platform_image":594,"categories":47},257,"FLEX SWILE","\u003Cp>Gravimetric pick & decision dispense of solids (matrix-to-matrix) - paradigm shift in solid / powder distribution / reformatting.\u003C/p>","gravimetric-pick-and-decision-dispense-of-solids","Versatile matrix-to-matrix gravimetric pick & decision dispense of solids","a65b4426-07ce-4504-9c25-9e58db2dc29c",{"id":596,"title":597,"description":598,"permalink":599,"name":600,"platform":574,"platform_image":594,"categories":47},258,"FLEX SWILE DSC","Step-change in end-to-end DSC sample preparation - gravimetric pick & decision dispense of solids / matrix-to-matrix reformatting.","gravimetric-pick-and-decision-dispense-for-dsc-sample-preparation","End-to-end DSC sample preparation",{"id":602,"title":603,"description":604,"permalink":605,"name":606,"platform":574,"platform_image":607,"categories":47},259,"FLEX SWILE for NMR LCMS Sample Prep","\u003Cp>Step-change in end-to-end NMR and LCMS sample preparation - gravimetric pick & decision dispense of solids / matrix-to-matrix reformatting, dissolution and online / offline NMR and / or LC-MS (incl. applications in GMP environments).\u003C/p>","end-to-end-nmr-and-lcms-sample-preparation","End-to-end NMR and LCMS sample preparation","05f14f17-0568-4bf5-893e-107c678a59c5",{"id":609,"title":610,"description":611,"permalink":612,"name":613,"platform":574,"platform_image":594,"categories":614},260,"FLEX SWILE catalyst screening","Paradigm shift in catalyst screening - gravimetric pick & dispense of ligands, catalyst precursors, catalysts.","pick-and-decision-dispense-of-solids-for-catalyst-screening","Matrix-to-matrix gravimetric pick & dispense of solids for catalyst screening",[615],"Fine and specialty chemicals catalysis",{"id":617,"title":618,"description":619,"permalink":620,"name":621,"platform":574,"platform_image":594,"categories":47},261,"FLEX SWILE compound management","Step-change in solid compound management - gravimetric pick & dispense of solids for e.g. biological screening.","gravimetric-pick-and-decision-dispense-of-solids-for-compound-management","Mother-to-daughter gravimetric pick & dispense of solids ",{"id":623,"title":624,"description":625,"permalink":626,"name":627,"platform":574,"platform_image":594,"categories":47},262,"FLEX SWILE formulation screening","Formulation screening enabled by fractional compositional mapping based on gravimetric pick & decision dispense of solids.","pick-and-decision-dispense-of-solids-for-formulation-screening","Fractional compositional mapping by gravimetric pick & dispense of solids",{"id":629,"title":630,"description":631,"permalink":632,"name":633,"platform":574,"platform_image":634,"categories":635},263,"FLEX ISYNTH for active ingredient library synthesis","\u003Cp>Automated, parallel library synthesis / lead optimization in drug discovery (medicinal chemistry).\u003C/p>","high throughput-library-synthesis-for-innovative-medicines","High throughput library synthesis for innovative, better medicines","4e3d39c4-ae0a-4583-82aa-a1eda6d8c789",[636,637],"Small Molecules Synthesis (e.g. organics, organometallics)","Drug discovery & MedChem innovation with automated solutions.",{"id":639,"title":640,"description":641,"permalink":642,"name":643,"platform":574,"platform_image":644,"categories":47},264,"FLEX ISYNTH for library synthesis and reaction screening with online/offline NMR","\u003Cp>Automated, parallel library synthesis and reaction screening with online benchtop NMR (e.g. automated synthesis, online characterization, data analysis, AI / ML closed loop).\u003C/p>","high-throughput-library-synthesis-with-online-nmr","High throughput library synthesis reaction screening with online NMR","0a08e1f7-c768-454c-a405-fe33360e7d8e",{"id":646,"title":647,"description":648,"permalink":649,"name":650,"platform":564,"platform_image":47,"categories":651},265,"ISYNTH for versatile synthesis","\u003Cp>High throughput library synthesis of organics, inorganics, and hybrid materials in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors with mixing, heating, refluxing, cooling, vacuum, inert gas.\u003C/p>","automated-library-synthesis","Automated, parallel library synthesis of e.g. organics, inorganics, nanomateriales",[567,652],"Polymer synthesis solutions",{"id":654,"title":655,"description":656,"permalink":657,"name":658,"platform":564,"platform_image":659,"categories":47},266,"ISYNTH AI for active ingredient synthesis","\u003Cp>Molecular diversity / molecule discovery in e.g. medicinal chemistry enabled by our high throughput library synthesis solutions in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors.\u003C/p>","automated-active-ingredients-ai-library-synthesis","Automated active ingredients (AI) library synthesis","ceb87b55-aab0-4965-866f-1139c24655d7",{"id":661,"title":662,"description":663,"permalink":664,"name":665,"platform":564,"platform_image":666,"categories":667},268,"ISYNTH CATSCREEN 96 for catalyst screening","\u003Cp>Unattended catalyst preparation / formation / assembly and screening at ambient and elevated pressure in verasatile 96-well plates with disposable glass vials / reactors.\u003C/p>","accelerated-catalyst-synthesis-and-screening-in-flexible-well-plate-formats","High throughput catalyst synthesis & screening in flexible well-plate formats","f8200e53-0f33-45c7-a1cb-74b035ee9172",[615],{"id":669,"title":670,"description":671,"permalink":672,"name":673,"platform":564,"platform_image":674,"categories":675},269,"ISYNTH SPEEDCHEM for superheated chemistry","\u003Cp>Automated, parallel synthesis in verasatile 96-well plates with disposable glass vials / reactors under accelerating superheated conditions (van't Hoff rule).\u003C/p>","isynth-speedchem","High throughput organics, inorganics, polymer synthesis under superheated, accelerated conditions","88c0a4da-a1f8-4d63-a87f-1935a93e46a0",[636,567,637],{"id":677,"title":678,"description":679,"permalink":680,"name":681,"platform":564,"platform_image":682,"categories":47},270,"SMOLE ","\u003Cp>Life science industry faces the increased demand for innovative, “Rule of five compatible small-molecule” medicines against various diseases. Time-to-market with an easily accessible but highly innovative API is essential.\u003Cbr>\u003Cbr>Gamification of Research & Development represents a paradigm shift in life science research. It enables flexibility, diversity, standardization, and speed in the entire discovery process, i.e. synthesis, purification, sample management, reformatting and biology testing, based on an unprecedented automation concept combined with SMOLE.\u003C/p>","smole","Take your classical & automated synthesis to hyper speed","4de8d2d1-8dc3-47c6-a0b8-e3e4d1477c3d",{"id":684,"title":685,"description":686,"permalink":687,"name":688,"platform":574,"platform_image":689,"categories":47},271,"FLEX FORMAX","FLEX FORMAX supports your digitalization process with automated workflow solutions for faster and better formulation development and formulation optimization. FLEX FORMAX modularity allows the user to execute and perform complex formulation workflows. High quality is assured by e.g. accurate viscosity, pH, temperature and stirring control.","flex-formax","Compact fully automated formulation","530fd90a-d35f-4e85-a113-7d1b8176a15b",{"id":691,"title":692,"description":693,"permalink":694,"name":695,"platform":564,"platform_image":696,"categories":47},272,"FORMAX","\u003Cp>Automated development, optimization, and characterization of formulations using no manual intervention.\u003C/p>","formax","Fully automated formulation development, optimization and characterization","2bdc3b63-fed5-4048-b89c-6bf3e7c84d8e",{"id":698,"title":699,"description":700,"permalink":701,"name":702,"platform":574,"platform_image":703,"categories":704},276,"FLEX RHEO","\u003Cp>Chemspeed’s FLEX RHEO allows fully automated rheology measurement for various workflows, using  Discovery HR rheometers, or other rheometers, for “Press Start and Walk Away” operation. With optional extras, including robotic pH measurement tool, screw capper and extended storage capacity, this Chemspeed configurable solution transforms the traditional rheology analysis process.\u003C/p>","flex-rheo","Fully automated rheology measurement","2024fa5b-43be-4e29-b634-647b2baaf950",[705],"(Bio-)Lubricants R&D and QC",{"id":707,"title":708,"description":709,"permalink":710,"name":711,"platform":564,"platform_image":712,"categories":47},278,"ISYNTH for library synthesis and reaction screening with online/offline NMR","\u003Cp>High-throughput library synthesis and reaction screening with online benchtop NMR (e.g. automated synthesis, online characterization, data analysis, AI / ML closed loop).\u003Cbr>\u003Cbr>The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our various reactor formats for conventional, MW-assisted, reactive gas, photochem synthesis and our user-friendly software enable you to accelerate, standardize, digitalize your library synthesis and reaction screening workflows.\u003C/p>","isynth-with-integrated-online-offline-nmr","Parallel, automated synthesis and reaction screening with online NMR","ba5eb0b6-61bf-453a-a508-fc1b631f901f",{"id":714,"title":715,"description":716,"permalink":717,"name":718,"platform":564,"platform_image":719,"categories":47},281,"SWING CRYSTAL","Crystallization, polymorph, salt and solubility screening in unique MTP blocks with bottom glass-plate for direct transfer to XRPD.\u003Cbr />\u003Cbr />\n\u003Cp> \u003C/p>","swing-crystal","Accelerated, standardized crystallization screening","d537b451-46c5-4af8-89e9-f3446686d5a7",{"id":721,"title":722,"description":723,"permalink":724,"name":725,"platform":564,"platform_image":726,"categories":47},284,"SWING RP","Automated solid and liquid reaction preparation for e.g. library synthesis, catalyst screening.","swing-rp","High throughput, versatile solid and liquid reaction preparation","947a6f82-3bcb-4db6-b7c3-dc3054d61a79",{"id":728,"title":729,"description":730,"permalink":731,"name":732,"platform":564,"platform_image":733,"categories":47},286,"SWING VISCODOSE","Overhead gravimetric viscous liquid, paste, wax dispensing WHILE sample processing (e.g. heating / cooling, mixing).","swing-viscodose","Automated overhead gravimetric viscous liquid, paste, or wax dispensing","f4f11cc6-1f91-4770-b9fc-5181e6b95bf5",{"id":735,"title":736,"description":737,"permalink":738,"name":739,"platform":564,"platform_image":740,"categories":47},287,"SWING FLEXYWEIGHER PLUS","Vial weighing, solid / liquid filling, cap screwing & unscrewing, capping & crimping (incl. applications in GMP environments).","swing-flexyweigher-plus","Automated vial weighing, solid / liquid filling, capping","dd16ac78-bb02-47b5-a193-8345be7a797c",{"id":742,"title":743,"description":744,"permalink":745,"name":746,"platform":564,"platform_image":47,"categories":47},289,"SWING","Versatile compound / substance handling for e.g. analytical sample preparation, reaction preparation, formulation, application and testing preparation.","swing","Automated gravimetric compound / substance handling and preparation",{"id":748,"title":749,"description":750,"permalink":751,"name":752,"platform":564,"platform_image":753,"categories":47},290,"SWING SPEEDEXTRACT","Automated parallel autogeneous pressure extraction.","swing-speedextract","High throughput pressure extraction","cda7f3c3-a039-4e76-94c3-f628f5464c27",{"id":755,"title":756,"description":757,"permalink":758,"name":759,"platform":564,"platform_image":760,"categories":761},291,"SWING Visco","\u003Cp>Automatically dispense virtually any product (low to high viscosity liquids, pastes, even melted waxes) and subsequently measure its viscosity with our proprietary overhead gravimetric dispensing technology in combination with our software.\u003C/p>","swing-visco","Automated sample preparation and viscosity measurement","008185b0-9e23-47c5-94dd-108b5fb6d6a8",[705],{"id":763,"title":764,"description":765,"permalink":766,"name":767,"platform":564,"platform_image":768,"categories":47},293,"SWING XDOSE","\u003Cp>Manual sample preparation for e.g. reactions, formulations, analysis is tedious, time-consuming and error-prone.\u003C/p>","swing-xdose","Automated gravimetric solid, powder, liquid, viscous liquid, wax dispensing","ae5bba0d-f1e5-4ed4-913f-3ec4e2e01c4c",{"id":770,"title":771,"description":772,"permalink":773,"name":774,"platform":564,"platform_image":775,"categories":47},294,"SWILE","\u003Cp>Unique matrix-to-matrix / mother-to-daughter solid reformatting enabled by our gravimetic pick & decision dispense (SWILE) from virtually any source into any destination.\u003C/p>","swile-compound-management","Step-change in solid reformatting / distribution","2cfb3a05-6652-465a-a955-2ba6b97159e5",{"id":777,"title":778,"description":779,"permalink":780,"name":781,"platform":574,"platform_image":782,"categories":47},295,"FLEX LIQUIDOSE","\u003Cp>Gravimetric dispensing of liquids from 1 mPa·s to 500’000+ mPa·s for any type of sample preparation.\u003C/p>","flex-liquidose","Gravimetric and/or volumetric liquid, viscous liquid, paste, cream, or wax dispensing","1f1734a8-cc7c-4494-b153-b764d8b2ee5d",{"id":784,"title":785,"description":786,"permalink":787,"name":788,"platform":564,"platform_image":789,"categories":790},299,"MULTIPLANT / AUTOPLANT PRORES for chemical development","\u003Cp>Quality by design (QbD), proven accetable range (PAR) driven automated process R&D / chemical development, scale-up and preparative synthesis.\u003C/p>","multiplant-autoplant-prores","High output process research / chemical development / scale-up","8286bdd8-3006-457a-9d14-92ed0edfbcd8",[791],"Chemical development solutions",{"id":793,"title":794,"description":795,"permalink":796,"name":797,"platform":564,"platform_image":798,"categories":47},301,"MULTIPLANT / AUTOPLANT for versatile process research","\u003Cp>Quality by design (QbD), proven accetable range (PAR) driven high output process R&D / chemical development and preparative synthesis.\u003C/p>","multiplant-autoplant","Automated chemical development for organics, inorganics, polymers","d4c99566-f907-4fc0-9950-ddd3767ce392",{"id":800,"title":801,"description":802,"permalink":803,"name":804,"platform":574,"platform_image":805,"categories":806},304,"FLEX AUTOPLANT for versatile process research","\u003Cp>Quality by design (QbD), proven accetable range (PAR) driven high-output process R&D / chemical development, preparative synthesis, work-up, and analysis.\u003C/p>","flex-autoplant"," Automated process R&D and preparative synthesis","ffb43088-f15a-46ea-9243-7bd0d2d0e0c5",[791,705],{"id":808,"title":809,"description":810,"permalink":811,"name":812,"platform":564,"platform_image":813,"categories":47},305,"SWING KF","\u003Cp>Determination of water content is key to ensure product quality, stability, shelf life and compliance with industry standards. \u003C/p>","swing-kf","Automated sample preparation and integrated inline Karl Fischer water titration","3a33d55f-c780-4a11-b92d-7357ca2c0d3c",{"id":815,"title":816,"description":817,"permalink":818,"name":819,"platform":564,"platform_image":820,"categories":47},307,"SWING MEDTECH","Gravimetric solid dispensing, blending, and microwave-assisted baking of powders.","swing-medtech","Automated preparation of bone cement","b7b219c0-b442-4322-9c0c-5797628d1243",{"id":822,"title":823,"description":824,"permalink":825,"name":826,"platform":564,"platform_image":16,"categories":47},308,"SWING MIXING POSSIBLE","To overcome potential limitations of mixing by shaking, magnetic bars, stirring, Chemspeed has combined its proprietary overhead gravimetric dispensing technology with ultimate dual asymmetric centrifuge mixing which equals \"mixing possible\".","swing-mixingpossible","High troughput sample preparation and mixing / grinding",{"id":828,"title":829,"description":830,"permalink":831,"name":832,"platform":564,"platform_image":833,"categories":834},309,"MULTIPLANT / AUTOPLANT AUTOCAL for parallel calorimetry","\u003Cp>Parallel, automated and real-time calorimetry in high-precision Qbd process reactors for e.g. safety.\u003C/p>","multiplant-autoplant-autocal","Parallel, high output real time calorimetry","1cc2a000-cd10-4d43-b64d-3d439aa35d21",[791],{"id":836,"title":837,"description":838,"permalink":839,"name":840,"platform":564,"platform_image":841,"categories":47},311,"MULTIPLANT / AUTOPLANT FLOWCHEM for continuous flow chemistry","\u003Cp>Automated all-in-one batch and / or flow chemistry with independent, precise process parameter control in each reactor, multistep reactions and workup with optional online benchtop NMR.\u003C/p>","multiplant-autoplant-flowchem","Automated batch & flow chemistry","e5b420b4-a9c0-4651-84f6-15636957ec76",{"id":843,"title":844,"description":845,"permalink":846,"name":847,"platform":564,"platform_image":848,"categories":47},315,"Emulsifier","\u003Cp>Chemspeed’s EMULSIFIER enables fully automated emulsion formulation screening combined with integrated testing / characterization (e.g. image analysis, PSD) for e.g. home care, personal care, nutrition, agrochemical applications, enhanced oil recovery.\u003C/p>","emulsifier","Automated emulsion formulation and characterization","16434ac9-3e62-4377-860e-55fab2fd1040",{"id":850,"title":851,"description":852,"permalink":853,"name":854,"platform":574,"platform_image":47,"categories":47},316,"FLEX SWIP","\u003Cp>Pharmaceutical industry faces the increased demand for innovative medicines against various diseases. In this regard, the compound library in pharmaceutical industry is the most valuable asset. However, the compound distribution from the library into the screening plates is often still done manually and binds highly qualified resources to very time-consuming, tedious, and error-prone tasks.\u003C/p>\n\u003Cp> \u003C/p>","flex-swip","Automated gravimetric pick & decision dispense of honey-like compounds",{"id":856,"title":857,"description":757,"permalink":858,"name":759,"platform":574,"platform_image":859,"categories":47},317,"FLEX Visco","flex-visco","d0c8f034-fd5d-4c89-8dd5-952b2e54e9c3",{"id":861,"title":862,"description":863,"permalink":864,"name":865,"platform":564,"platform_image":866,"categories":47},318,"SWING SP","high throughput, versatile sample preparation with inherent data integrity.","swing-sp","Automated sample preparation for analytics, QC & preformulation","f58f58e6-5e20-49d4-9e44-2dc31e6d3ea5",{"id":868,"title":869,"description":870,"permalink":871,"name":872,"platform":564,"platform_image":873,"categories":874},321,"ISYNTH REACTSCREEN for reaction screening","Automated small-molecule reaction screening (μL to mL scale) in e.g. late-stage drug discovery / lead optimization.","isynth-reactscreen","Automated reaction screening (μL to mL scale)","dd5a7cf0-c733-406c-98ea-75cc5366afb9",[636,615,637],{"id":876,"title":877,"description":878,"permalink":879,"name":880,"platform":564,"platform_image":881,"categories":882},322,"ISYNTH SWAVE for MW-assisted synthesis","\u003Cp>Automated microwave assisted synthesis and sample treatment.\u003Cbr>\u003Cbr>\u003C/p>\n\u003Cp> \u003C/p>","isynth-swave","High throughput microwave assisted synthesis and sample treatment","578527ee-b814-403e-9857-2909b08f5b2e",[636,567,637],{"id":884,"title":885,"description":886,"permalink":887,"name":888,"platform":574,"platform_image":889,"categories":47},326,"FLEX EP","\u003Cp>Flex EP – compliance ready workstation with assured business continuity, seamlessly integrated into your lab information management system.\u003Cbr>\u003Cbr>Fully compliant with FDA 21 CFR part 11 and GAMP 5.\u003C/p>","flex-ep","Automated eluent preparation under GxP","e15893c3-29b3-46c8-96e1-5427063f56e8",{"id":891,"title":892,"description":893,"permalink":894,"name":895,"platform":574,"platform_image":896,"categories":47},327,"FLEX CATSCREEN","Unattended catalyst preparation and screening at ambient and elevated pressure in versatile 96-well plates with disposable glass vials / reactors.","flex-catscreen","High throughput catalyst preparation & screening ","fd5e198a-a8d2-47f5-a6d8-90e2752efece",{"id":898,"title":899,"description":900,"permalink":901,"name":902,"platform":574,"platform_image":903,"categories":47},328,"FLEX SPEEDCHEM","\u003Cp>Automated, parallel library synthesis in verasatile 96-well plates with disposable glass vials / reactors under accelerating superheated conditions (van't Hoff rule).\u003C/p>","flex-speedchem","High throughput library synthesis in disposable vials / reactors under accelerating superheated conditions","99e71de5-14a0-409e-ac20-7194e644857a",{"id":905,"title":906,"description":907,"permalink":908,"name":909,"platform":910,"platform_image":47,"categories":911},329,"FLEXSHUTTLE PHARMA RESEARCH","\u003Cp>Chemspeed's FLEXSHUTTLE is the step-changing solution for drug discovery workflows.\u003Cbr />This solution, as with all Chemspeed systems, can be easily expanded at virtually any time (higher throughput, modified specifications, features, workflows, etc.).\u003C/p>","flexshuttle-pharma-research","Fully automated synthesis, purification, chemical analysis and biological testing of drugs","FlexShuttle",[636,637],{"id":913,"title":914,"description":915,"permalink":916,"name":917,"platform":574,"platform_image":47,"categories":47},332,"FLEX YODA Dispenser","Chemspeed's YODA tool allows for quick, highly-accurate dispensing of versatile solids using a combination of the unique YODA dispensing technology and an integrated balance.","flex-yoda","Fast, highly precise dispensing of versatile solid materials",{"id":919,"title":920,"description":921,"permalink":922,"name":923,"platform":574,"platform_image":924,"categories":47},336,"FLEX ISYNTH for materials synthesis and crystallization with online / offline XRD","\u003Cp>Automated, parallel materials library synthesis (e.g. MOFs, perovskites) and crystallization optimization (e.g. active ingredients) with online benchtop XRD.\u003C/p>","flex-isynth-with-online-xrd","High throughput materials synthesis and crystallization with online XRD","871c7867-3a53-4324-9c8c-d6585de8e4d5",{"id":926,"title":927,"description":928,"permalink":929,"name":930,"platform":574,"platform_image":931,"categories":47},337,"FLEX AUTOPLANT for process research with online / offline NMR","\u003Cp>Quality by design (QbD), proven accetable range (PAR) driven high-output process R&D / chemical development, preparative synthesis, work-up, and analysis with online / offline benchtop NMR.\u003C/p>","flex-autoplant-with-online-offline-nmr","High output process research with online NMR","29b5fc95-1a43-484b-9025-4e61d410d449",{"id":933,"title":934,"description":935,"permalink":936,"name":937,"platform":574,"platform_image":938,"categories":47},338,"FLEX AUTOPLANT for materials synthesis and crystallization with online / offline XRD","\u003Cp>Quality by design (QbD), proven accetable range (PAR) driven high-output process R&D / chemical development, preparative synthesis, work-up, and analysis with online / offline benchtop XRD.\u003C/p>","flex-autoplant-xrd","High output materials synthesis and crystallization with online XRD","9d1a875f-6ec1-4cfd-9ea5-e8990565f06b",{"id":940,"title":941,"description":942,"permalink":943,"name":944,"platform":574,"platform_image":945,"categories":47},340,"FLEX AUTOPLANT for process research with online IR","\u003Cp>Quality by design (QbD), proven accetable range (PAR) driven high-output process R&D / chemical development, preparative synthesis, work-up, and analysis with online benchtop IR.\u003C/p>","flex-autoplant-with-online-ir","High output chemical development with online IR","6dd63908-0f77-4352-8c37-9d94bee4a683",{"id":947,"title":948,"description":949,"permalink":950,"name":951,"platform":574,"platform_image":952,"categories":47},344,"FLEX POWDER L","\u003Cp>The FLEX POWDER L automatic gravimetric dispensing system is designed for precise, automated handling of large quantities of solids and powders. \u003Cbr>The system ensures efficient, accurate, and reproducible dispensing regardless of solid morphology through a robust, modular platform.\u003C/p>","automatic-gravimetric-dispensing-system-for-large-amounts-of-solids-and-powders","Automatic gravimetric dispensing system for large amounts of solids and powders (100's mg to kg)","d22cceb4-bd53-449a-9bad-3e168e7804ae",{"id":954,"title":955,"description":956,"permalink":957,"name":958,"platform":574,"platform_image":959,"categories":47},345,"FLEX POWDER M (Yoda)","\u003Cp>This system is purpose-built for precise, automated one-to-one transfer of medium amounts of solids and powders.\u003C/p>\n\u003Cp>It combines gravimetric accuracy with a fully integrated robotic platform, enabling secure, hands-free material handling from storage to sample vessel. Ideal for labs requiring traceability, reproducibility, and efficient solid dispensing workflows.\u003C/p>","automatic-gravimetric-one-to-one-transfer-system-for-solids-and-powders"," Automatic Gravimetric One-to-One Transfer System for Solids and Powders","054e8d48-e017-413d-baef-f50ec4746a0e",{"id":961,"title":962,"description":963,"permalink":964,"name":965,"platform":574,"platform_image":966,"categories":47},374,"Sample Prep for Offline/Online NMR","\u003Cp>Chemspeed’s precision liquid handling solution in accordance with the international standard ISO 8655 enables fully automated, accurate, and reproducible preparation of liquid samples for high‑field offline / online MR analysis. The platform minimizes manual steps and ensures consistently high‑quality samples for reliable analytical results.\u003C/p>","precision-liquid-sample-preparation-for-high-field-nmr-analysis"," Precision Liquid Sample Preparation for Offline / Online High‑Field NMR Analysis","d5447bb1-8709-4b55-8598-4b97dd6555d2",{"id":968,"title":969,"description":970,"permalink":971,"name":972,"platform":574,"platform_image":973,"categories":47},375,"Process Research and Online NMR","\u003Cp>A fully automated, Quality‑by‑Design (QbD) and proven acceptable range (PAR)–driven solution enabling high‑output process R&D, chemical development, preparative synthesis, reaction work‑up, and analytical evaluation using online and offline benchtop NMR.\u003C/p>","automated-process-research-chemical-development-with-online-nmr-analysis","Automated Process Research / Chemical Development with Online NMR Analysis","9b596d63-6ba6-49bb-8062-e414c7f4bb9e",{"id":975,"title":976,"description":977,"permalink":978,"name":976,"platform":574,"platform_image":979,"categories":47},376,"At-line Solutions To Streamline Analytics and Quality Control Testing","\u003Cdiv class=\"introtext contentstage stage abstractcomponent aem-GridColumn aem-GridColumn--default--12\">\n\u003Cdiv class=\"ui-layout__responsive\">\n\u003Cdiv class=\"aem-introtext ui-separator\">\n\u003Cdiv class=\"aem-introtext__text ui-typography--intro\">\n\u003Cp>SciYbotic / Chemspeed's FLEX BENCH is a range of at-line solutions designed to streamline analytics and quality control testing. With e.g. SciY’s digitalization platform at its core, SciYbotic Quality Test Machines are deployable across the life sciences value chain, from the laboratory to commercial-scale,  including Good Manufacturing Practice (GMP) environments. This series includes our Tablet Tester systems.\u003C/p>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003Cdiv class=\"twocolumns columns responsivegrid aem-GridColumn aem-GridColumn--default--12\">\n\u003Cdiv class=\"ui-layout__responsive\">\n\u003Cdiv class=\"ui-separator \">\n\u003Cdiv class=\"aem-headline\"> \u003C/div>\n\u003Cdiv class=\"aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--phone--12  ui-styles__background-item\">\n\u003Cdiv class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--8 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n\u003Cdiv class=\"aem-Grid aem-Grid--8 aem-Grid--default--8 aem-Grid--phone--12 \">\n\u003Cdiv class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--8\">\n\u003Cdiv class=\"aem-text\">\n\u003Cdiv class=\"ui-typography--richtext\"> \u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>","sciybotic-quality-test-machines","13c5b93f-a2cb-4158-954f-73639c5009af",{"id":981,"title":982,"description":983,"permalink":984,"name":982,"platform":574,"platform_image":985,"categories":47},377,"Tablet Test System - IR (Bruker FT-NIR Multi Purpose Analyzer)","\u003Cdiv class=\"introtext contentstage stage abstractcomponent aem-GridColumn aem-GridColumn--default--12\">\n\u003Cdiv class=\"ui-layout__responsive\">\n\u003Cdiv class=\"aem-introtext ui-separator\">\n\u003Cdiv class=\"aem-introtext__text ui-typography--intro\">\n\u003Cp>The SciYbotic / Chemspeed FLEX TT is an automated solution for oral solid dosage (OSD) quality control, designed to deliver reliable at-line testing to ensure consistent product quality. It measures tablet weight, thickness, hardness, content uniformity, and assay. TT-IR integrates a Bruker MPA (FT-NIR Multi Purpose Analyzer) and works seamlessly with existing workflows. The system enables method transfer from lab to production and operates under GLP/GMP. TT-IR ensures consistent product quality during batch and continuous manufacturing by rapidly detecting out-of-specification tablets.\u003C/p>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003Cdiv class=\"highlightfacts responsivegrid aem-GridColumn aem-GridColumn--default--12\">\n\u003Cdiv class=\"ui-layout__responsive\">\n\u003Cdiv class=\"aem-highlightfacts ui-separator\">\n\u003Cdiv class=\"aem-headline\"> \u003C/div>\n\u003Cdiv class=\"aem-highlightfacts__columns\">\n\u003Cdiv class=\"aem-highlightfacts__column aem-highlightfacts__column--left\">\n\u003Cdiv class=\"highlightitem section\">\n\u003Cdiv class=\"aem-highlightfacts__item-wrapper aem-highlightfacts__item-wrapper--1\">\n\u003Cdiv class=\"aem-highlightfacts__item aem-highlightfacts__item--1\">\n\u003Cdiv class=\"aem-highlightfacts__claim-wrap\"> \u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>","sciybotic-tablet-test-machine-ir","78ea2527-cefd-4e56-9697-c85e16f5cd2e",{"id":987,"title":988,"description":989,"permalink":990,"name":988,"platform":47,"platform_image":991,"categories":47},378,"Leading Knowledge Manager and Quality-Centric Control Software Suite (synTQ)","\u003Cdiv class=\"introtext contentstage stage abstractcomponent aem-GridColumn aem-GridColumn--default--12\">\n\u003Cdiv class=\"ui-layout__responsive\">\n\u003Cdiv class=\"aem-introtext ui-separator\">\n\u003Cdiv class=\"aem-introtext__text ui-typography--intro\">\n\u003Cp>synTQ (synchronised Total Quality) is a leading knowledge manager and quality-centric control software suite that empowers manufacturers to achieve smarter, faster, and more consistent production. By unifying real-time data, process control, and advanced analytics, synTQ helps organizations accelerate product development, optimize manufacturing efficiency, and ensure regulatory compliance, all within a single, scalable system trusted by industry leaders worldwide.\u003C/p>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003Cdiv class=\"highlightfacts responsivegrid aem-GridColumn aem-GridColumn--default--12\">\n\u003Cdiv class=\"ui-layout__responsive\">\n\u003Cdiv class=\"aem-highlightfacts ui-separator\">\n\u003Cdiv class=\"aem-headline\"> \u003C/div>\n\u003Cdiv class=\"aem-highlightfacts__columns\">\n\u003Cdiv class=\"aem-highlightfacts__column aem-highlightfacts__column--left\">\n\u003Cdiv class=\"highlightitem section\">\n\u003Cdiv class=\"aem-highlightfacts__item-wrapper aem-highlightfacts__item-wrapper--1\">\n\u003Cdiv class=\"aem-highlightfacts__item aem-highlightfacts__item--1\">\n\u003Cdiv class=\"aem-highlightfacts__claim-wrap\"> \u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>\n\u003C/div>","syntq","652a9920-db5c-45c7-90de-01f0567a2979",{"id":993,"title":994,"description":995,"permalink":996,"name":994,"platform":574,"platform_image":997,"categories":47},379,"End-to-End \"Make\" and Multi-Modality Raman Spectroscopy & NMR Automation","\u003Cp>Seamlessly integrate Raman spectroscopy and NMR into automated laboratory workflows for e.g. analytical sample preparation, synthesis, process research, formulation. Our advanced automation solutions enable reproducible measurements, higher throughput, and consistent data quality—from research to routine analysis.\u003C/p>","advanced-raman-spectroscopy-nmr-automation","e568c6c5-8ff2-41da-9824-c219ffff5164",{"id":999,"title":1000,"description":1001,"permalink":1002,"name":1000,"platform":574,"platform_image":1003,"categories":47},380,"End-to-End \"Make\" and Multi-Modality Raman Spectroscopy & XRD Automation","\u003Cdiv>\n\u003Cp>Advanced automation in analytical sample preparation, synthesis, process research, formulation combining mulit-modality Raman spectroscopy and X-ray diffraction (XRD) enables efficient, reproducible analysis of both molecular and crystalline structures. These automated workflows reduce manual handling, increase throughput, and deliver consistent, high-quality data across research and routine applications.\u003C/p>\n\u003C/div>","advanced-raman-spectroscopy-xrd-automation","45d7092c-60eb-4a98-97c6-533b0804dc8c",[1005,1011,1017,1023,1029,1035,1041,1047,1053,1059,1065,1071,1077,1082,1088,1094,1100,1106,1112,1118,1123,1129,1135,1141,1147,1153,1159,1165,1171,1177,1183,1189,1195,1201,1207,1213,1219,1225,1231,1237,1243,1249,1255,1262,1269,1276,1283,1289,1295,1302,1309,1315,1322,1328,1334,1340,1346,1352,1359,1366,1372,1379,1386,1393,1400,1406,1412,1418,1424,1430,1436,1441,1447,1453,1459,1465,1469,1474,1480,1486,1492,1498,1504,1510,1516,1522,1528,1533,1539,1545,1551,1556,1562,1567,1573,1579,1585,1591,1597,1603,1609,1615,1621,1627,1633,1638,1644,1649,1655,1661,1667,1673,1679,1685,1691,1697,1702,1708,1713,1719,1725,1731,1737,1742],{"id":1006,"title":1007,"url":1008,"preview":1009,"target_date":1010,"picture":47},14013,"Integration of Machine Learning and Automated Synthesis for Accelerated Drug and Material Research","integration-of-machine-learning-and-automated-synthesis-for-accelerated-drug-and-material-research-integration-of-machine-learning-and-automated-synthesis-for-accelerated-drug-and-material-research","\u003Cp>The challenges posed by global climate change and disease risks have intensified the demand for efficient and practical materials and molecules. Traditional trial-and-error approaches are becoming increasingly inefficient and resource-intensive. The rapid advancement of artificial intelligence (AI) has opened new avenues to accelerate research and shorten development cycles.\u003C/p>","2026-06-02",{"id":1012,"title":1013,"url":1014,"preview":1015,"target_date":1016,"picture":47},14012,"Localization, inspection, and reasoning (LIRA) module for autonomous workflows in self-driving laboratories","localization-inspection-and-reasoning-lira-module-for-autonomous-workflows-in-self-driving-laboratories","\u003Cp>Self-driving labs (SDLs) combine robotic automation with artificial intelligence (AI) to allow autonomous, high-throughput experimentation. However, robot manipulation in most SDL workflows operates in an open-loop manner, lacking real-time error detection and error correction. This can reduce reliability and overall efficiency.\u003C/p>","2026-05-05",{"id":1018,"title":1019,"url":1020,"preview":1021,"target_date":1022,"picture":47},14027,"An Automation Platform for the Chemoenzymatic Synthesis of Complex Sulfated and Branched Glycans","an-automation-platform-for-the-chemoenzymatic-synthesis-of-complex-sulfated-and-branched-glycans","\u003Cp>Diverse collections of well-defined glycans are needed to investigate the molecular mechanisms by which these biomolecules mediate biological and disease processes. Several automation approaches have been introduced to accelerate the enzymatic synthesis of complex glycans. These methodologies have, however, provided only relatively simple oligosaccharides due to limitations of glycosyl transferase selectivity.\u003C/p>","2026-04-28",{"id":1024,"title":1025,"url":1026,"preview":1027,"target_date":1028,"picture":47},14020,"Implementation of Large-Scale Multi-Reactor Automation for Process Development","implementation-of-large-scale-multi-reactor-automation-for-process-development","\u003Cp>Pharmaceuticals increasing complexity requires longer synthesis with unique processes for each step, increasing the number of experiments to develop robust sustainable processes. The time to develop these processes is getting shorter, and automation can support the growing need to efficiently perform more experiments.\u003C/p>","2026-04-14",{"id":1030,"title":1031,"url":1032,"preview":1033,"target_date":1034,"picture":47},14023,"synTQ: The Intelligence Layer Powering Automated QC and Smart Manufacturing","syn-tq-the-intelligence-layer-powering-automated-qc-and-smart-manufacturing","\u003Cp>In modern pharmaceutical and bioprocess manufacturing environments, automation alone is no longer enough. True digital transformation requires every instrument, robot, sensor, and workflow to operate with precision, reliability, and complete data integrity. \u003C/p>","2026-02-26",{"id":1036,"title":1037,"url":1038,"preview":1039,"target_date":1040,"picture":47},14016,"Artificial intelligence-driven autonomous laboratory for accelerating chemical discovery","artificial-intelligence-driven-autonomous-laboratory-for-accelerating-chemical-discovery","\u003Cp>Autonomous laboratories, also known as self-driving labs, have emerged as a powerful strategy to accelerate chemical discovery. By highly integrating different key parts including artificial intelligence (AI), robotic experimentation systems and automation technologies into a continuous closed-loop cycle, autonomous laboratories can efficiently conduct scientific experiments with minimal human intervention.\u003C/p>","2026-02-24",{"id":1042,"title":1043,"url":1044,"preview":1045,"target_date":1046,"picture":47},14019,"Toward fully autonomous closed-loop molecular discovery – A case study on JAK targets","toward-fully-autonomous-closed-loop-molecular-discovery-a-case-study-on-jak-targets","\u003Cp>Bridging AI and self-driving laboratories, we introduce the first fully-automated, closed-loop molecular discovery cycle, exemplified by the identification of novel JAK inhibitors. With minimal human intervention, we combined AI-driven molecular design and retrosynthesis with IBM’s synthesis automation system RoboRXN and Arctoris’ Ulysses platform for automated in-vitro screening.\u003C/p>","2026-02-03",{"id":1048,"title":1049,"url":1050,"preview":1051,"target_date":1052,"picture":47},14003,"Asymmetric hydrogenation of olefins with transition metal-based catalysts: practical insights from screening to production of APIs","asymmetric-hydrogenation-of-olefins-with-transition-metal-based-catalysts-practical-insights-from-screening-to-production-of-apis","\u003Cp>Selective hydrogenation plays a critical role in modern synthetic chemistry, particularly in the pharmaceutical industry, where the production of chiral molecules with high enantiomeric purity is essential for the efficacy and safety of active pharmaceutical ingredients (APIs). \u003C/p>","2026-01-20",{"id":1054,"title":1055,"url":1056,"preview":1057,"target_date":1058,"picture":47},14015,"Automated synthesis and fragment descriptor-based machine learning for retention time prediction in supercritical fluid chromatography","automated-synthesis-and-fragment-descriptor-based-machine-learning-for-retention-time-prediction-in-supercritical-fluid-chromatography","\u003Cp>The integration of automated synthesis and machine learning (ML) is transforming analytical chemistry by enabling data-driven approaches to method development. Chromatographic column selection, a critical yet time-consuming step in separation science, stands to benefit substantially from such advances.\u003C/p>","2026-01-06",{"id":1060,"title":1061,"url":1062,"preview":1063,"target_date":1064,"picture":47},14001,"Thinking Outside the Library: Cluster Synthesis of Diverse Molecules on a Single Robotic Platform","thinking-outside-the-library-cluster-synthesis-of-diverse-molecules-on-a-single-robotic-platform","\u003Cp>The development of a general autonomous platform for organic synthesis that enables faster, flexible and efficient delivery of target molecules is an attractive strategy for many fields such as drug discovery and material sciences.\u003C/p>","2025-12-16",{"id":1066,"title":1067,"url":1068,"preview":1069,"target_date":1070,"picture":47},13996,"Design and Implementation of a High-Throughput Experimentation Platform to Accelerate Drug Discovery","design-and-implementation-of-a-high-throughput-experimentation-platform-to-accelerate-drug-discovery","\u003Cp>Herein, we describe the development of the high-throughput experimentation platform and function in AbbVie’s Discovery Chemistry organization.\u003C/p>","2025-11-25",{"id":1072,"title":1073,"url":1074,"preview":1075,"target_date":1076,"picture":47},13992,"Kinetically guided exploration of photocatalytic reactions by combining automation with in situ measurements","kinetically-guided-exploration-of-photocatalytic-reactions-by-combining-automation-with-in-situ-measurements","\u003Cp>Photocatalysis enables valuable reactions such as synthetic transformations or energy conversion processes like water splitting. To rationally improve photocatalytic reactions, mechanistic insights are required. These can be obtained with kinetic measurements, which are, however, difficult to obtain for a large enough number of reaction conditions to provide systematic and valuable insights. \u003C/p>","2025-09-09",{"id":1078,"title":1079,"url":1080,"preview":47,"target_date":1081,"picture":47},13990,"How AI is driving R&D productivity ","how-ai-is-driving-r-and-d-productivity-","2025-09-02",{"id":1083,"title":1084,"url":1085,"preview":1086,"target_date":1087,"picture":47},13980,"The Implementation and Impact of Chemical High-Throughput Experimentation at AstraZeneca","implementation-and-impact-of-chemical-high-throughput-experimentation-at-astra-zeneca","\u003Cp>High-throughput experimentation (HTE) is a critical tool in modern pharmaceutical discovery and development.\u003C/p>","2025-08-26",{"id":1089,"title":1090,"url":1091,"preview":1092,"target_date":1093,"picture":47},13977,"Data-Led Suzuki-Miyaura Reaction Optimization: Development of a Short Course for Postgraduate Synthetic Chemists","development-of-a-short-course-for-postgraduate-synthetic-chemists","\u003Cp>A two-day workshop activity is described in which postgraduate students are introduced to (i) the theory and application of Design-of-Experiments (DOE) approaches and (ii) the implementation of affordable automation technologies and related data analysis of a system of catalytic interest.\u003C/p>","2025-07-15",{"id":1095,"title":1096,"url":1097,"preview":1098,"target_date":1099,"picture":47},13987,"Chemspeed Highlights Future of Lab Automation on MestreCast Podcast","chemspeed-highlights-future-of-lab-automation-on-mestre-cast-podcast","\u003Cp class=\"\" data-start=\"185\" data-end=\"534\">\u003Cspan class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Chemspeed Technologies is proud to share insights from our CTO, Mathias Cherbuin, featured in the latest episode of Mestrelab’s \u003Cem data-start=\"128\" data-end=\"140\">MestreCast\u003C/em> podcast, titled “Innovation in Lab Automation and Digitalization.”\u003C/span> \u003Cspan class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">In this engaging conversation with Mestrelab CEO Santi Dominguez, Mathias divves into the evolving landscape of laboratory automation, the integration of hardware and software, and the transformative impact of AI-driven workflows\u003C/span>\u003C/p>","2025-07-01",{"id":1101,"title":1102,"url":1103,"preview":1104,"target_date":1105,"picture":47},13975,"General data management workflow to process tabular data in automated and high-throughput heterogeneous catalysis research","streamlined-standardized-data-workflows-for-automated-high-throughput-laboratories","\u003Cp>Data management and processing are crucial steps to implement streamlined and standardized data workflows for automated and high-throughput laboratories. Electronic laboratory notebooks (ELNs) have proven to be effective to manage data in combination with a laboratory information management system (LIMS) to connect data and inventory.\u003C/p>","2025-06-12",{"id":1107,"title":1108,"url":1109,"preview":1110,"target_date":1111,"picture":47},13979,"Artificial intelligence—the great job maker or taker?","artificial-intelligence-the-great-job-maker-or-taker","\u003Cp>Artificial intelligence is enabling chemists to rapidly identify novel compounds and substantially improve the efficiency of manufacturing processes. Developers of chemistry-related AI systems argue that their technologies will unleash a wave of new compounds that will require chemists to evaluate and test them.\u003C/p>","2025-06-03",{"id":1113,"title":1114,"url":1115,"preview":1116,"target_date":1117,"picture":47},13940,"Artificial Intelligence-Driven Development of Nickel-Catalyzed Enantioselective Cross-Coupling Reactions","artificial-intelligence-driven-development-of-nickel-catalyzed-enantioselective-cross-coupling-reactions","\u003Cp>The conventional approach to developing asymmetric synthetic methods relies heavily on empirical optimization. However, the integration of artificial intelligence (AI) and highthroughput experimentation (HTE) technology presents a paradigm shift with immense potential to revolutionize the discovery and optimization of asymmetric reactions.\u003C/p>","2025-05-20",{"id":1119,"title":1120,"url":1121,"preview":1122,"target_date":1117,"picture":47},13985,"Highlight Crystal Powderdose installation at Ghent University's HighTru lab","highlight-crystal-powderdose-installation-at-ghent-universitys-high-tru-lab","\u003Cp>High-Throughput Experimentation (HTE) is a method where a large number of experiments are conducted simultaneously using automated equipment and robotics. It is now being introduced in chemistry and pharmaceutical sciences to quickly collect and analyze large amounts of data.\u003C/p>",{"id":1124,"title":1125,"url":1126,"preview":1127,"target_date":1128,"picture":47},13933,"Illuminating ‘the ugly side of science’: fresh incentives for reporting negative results","illuminating-the-ugly-side-of-science-fresh-incentives-for-reporting-negative-results","\u003Cp>New data repositories and alternative journals and workshops offer routes for sharing negative results — which could help to solve the reproducibility crisis and give machine learning a boost.\u003C/p>","2025-05-13",{"id":1130,"title":1131,"url":1132,"preview":1133,"target_date":1134,"picture":47},13941,"Light-Driven Hybrid Nanoreactor Harnessing the Synergy of Carboxysomes and Organic Frameworks for Efficient Hydrogen Production","light-driven-hybrid-nanoreactor-harnessing-the-synergy-of-carboxysomes-and-organic-frameworks-for-efficient-hydrogen-production","\u003Cp>Synthetic photobiocatalysts are promising catalysts for valuable chemical transformations by harnessing solar energy inspired by natural photosynthesis. However, the synergistic integration of all of the components for efficient light harvesting, cascade electron transfer, and efficient biocatalytic reactions presents a formidable challenge.\u003C/p>","2025-03-18",{"id":1136,"title":1137,"url":1138,"preview":1139,"target_date":1140,"picture":47},13938,"Autonomous Optimization of Discrete Reaction Parameters: Mono-Functionalization of a Bifunctional Substrate via a Suzuki-Miyaura Reaction","autonomous-optimization-of-discrete-reaction-parameters","\u003Cp>The systematic, autonomous optimization of discrete reaction parameters in organic synthesis remains unexplored, offering the potential to revolutionize synthetic methodology and expand the scope and efficiency of reaction development.\u003C/p>","2025-01-28",{"id":1142,"title":1143,"url":1144,"preview":1145,"target_date":1146,"picture":47},13946,"Overcoming DMTA Cycle Challenges: A Unified AI-Driven System for Efficient Drug Design","overcoming-dmta-cycle-challenges-a-unified-ai-driven-system-for-efficient-drug-design","\u003Cp>The integration of artificial intelligence (AI) and machine learning (ML) in drug design has the potential to transform small molecule drug discovery in the pharmaceutical industry, enhancing the efficiency and productivity of the drug design and discovery process.\u003C/p>","2025-01-14",{"id":1148,"title":1149,"url":1150,"preview":1151,"target_date":1152,"picture":47},13927,"GLAS: An open-source easily expandable Git-based Scheduling Architecture for Integral Lab Automation","glas-an-open-source-easily-expandable-git-based-scheduling-architecture-for-integral-lab-automation","\u003Cp>This paper presents GLAS (Git-based Lab Automated Scheduler or Get Lab Automation Simplified), an open-source, robust, and highly expandable Git-based architecture designed for laboratory automation.\u003C/p>","2024-12-24",{"id":1154,"title":1155,"url":1156,"preview":1157,"target_date":1158,"picture":47},13921,"Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction","development-of-a-high-throughput-kinetics-protocol-and-application-to-an-aza-michael-reaction","\u003Cp>High-throughput experimentation (HTE) has become integral to the pharmaceutical industry with most major pharmaceutical companies investing in automation and high-throughput screening technologies.\u003C/p>","2024-10-29",{"id":1160,"title":1161,"url":1162,"preview":1163,"target_date":1164,"picture":47},13916,"Deciphering complexity in Pd–catalyzed cross-couplings","deciphering-complexity-in-Pd–catalyzed-cross-couplings","\u003Cp>Understanding complex reaction systems is critical in chemistry. While synthetic methods for selective formation of products are sought after, oftentimes it is the full reaction signature, i.e., complete profile of products/side-products, that informs mechanistic rationale and accelerates discovery chemistry.\u003C/p>","2024-08-13",{"id":1166,"title":1167,"url":1168,"preview":1169,"target_date":1170,"picture":47},13914,"Automated approaches, reaction parameterisation, and data science in organometallic chemistry and catalysis: towards improving synthetic chemistry and accelerating mechanistic understanding","automated-approaches-reaction-parameterisation-and-data-science-in-organometallic-chemistry-and-catalysis-towards-improving-synthetic-chemistry-and-accelerating-mechanistic-understanding","\u003Cp>Automation technologies and data science techniques have been successfully applied to optimisation and discovery activities in the chemical sciences for decades.\u003C/p>","2024-08-06",{"id":1172,"title":1173,"url":1174,"preview":1175,"target_date":1176,"picture":47},13917,"Streamlining Catalysis Screenings on a Budget","streamlining-catalysis-screenings-on-a-budget","\u003Cp>Striving for efficiency within chemical development, lab automation is unequivocally on the run. With a plethora of technology available off the shelves, holistic platforms that automate full workstreams have been a target of the industry\u003C/p>","2024-07-23",{"id":1178,"title":1179,"url":1180,"preview":1181,"target_date":1182,"picture":47},13908,"Automated Intelligent Platforms for High‐Throughput Chemical Synthesis","automated-iIntelligent-platforms-for-high‐throughput-chemical-synthesis","\u003Cp>Automation and high-throughput techniques provide a solid technical foundation for realizing the deep fusion of artificial intelligence and chemistry as well as the full utilization of their advantages.\u003C/p>","2024-07-09",{"id":1184,"title":1185,"url":1186,"preview":1187,"target_date":1188,"picture":47},13906,"Biophysical Characterization and Cryopreservation of Mammalian Cells Using Ionic Liquids","biophysical-characterization-and-cryopreservation-of-mammalian-cells-using-ionic-liquids","\u003Cp>Ionic liquids (ILs) are a diverse class of solvents which can be selected for task-specific properties, making them attractive alternatives to traditional solvents.\u003C/p>","2024-06-25",{"id":1190,"title":1191,"url":1192,"preview":1193,"target_date":1194,"picture":47},13905,"Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library","multivariate-analysis-of-cellular-uptake-characteristics-for-a-co-polymer-particle-library","\u003Cp>Controlling cellular responses to nanoparticles so far is predominantly empirical, typically requiring multiple rounds of optimization of particulate carriers.\u003C/p>","2024-06-11",{"id":1196,"title":1197,"url":1198,"preview":1199,"target_date":1200,"picture":47},13907,"Streamlining the Generation of Advanced Polymer Materials through the Marriage of Automation and Multiblock Copolymer Synthesis in Emulsion","streamlining-the-generation-of-advanced-polymer-materials-through-the-marriage-of-automation-and-multiblock-copolymer-synthesis-in-emulsion","\u003Cp>Synthetic polymers are of paramount importance - an incredibly wide range of polymeric materials possessing an impressive variety of properties have been developed to date.\u003C/p>","2024-05-28",{"id":1202,"title":1203,"url":1204,"preview":1205,"target_date":1206,"picture":47},13901,"Lyotropic liquid crystal phases of monoolein in protic ionic liquids","lyotropic-liquid-crystal-phases-of-monoolein-in-protic-ionic-liquids","\u003Cp>Monoolein-based liquid crystal phases are established media that are researched for various biological applications, including drug delivery.\u003C/p>","2024-04-02",{"id":1208,"title":1209,"url":1210,"preview":1211,"target_date":1212,"picture":47},13898,"MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery","microcycle","\u003Cp>We herein describe the development and application of a modular technology platform which incorporates recent advances in plate-based microscale chemistry, automated purification, in situ quantification, and robotic liquid handling to enable rapid access to high-quality chemical matter already formatted for assays.\u003C/p>","2024-03-19",{"id":1214,"title":1215,"url":1216,"preview":1217,"target_date":1218,"picture":47},13899,"Harnessing the Power of C-H Functionalization Chemistry to Accelerate Drug Discovery","harnessing-the-power-of-c-h-functionalization-chemistry-to-accelerate-drug-discovery","\u003Cp>The field of C-H functionalization chemistry has experienced rapid growth in the past twenty years, with increasingly powerful applications in organic synthesis.\u003C/p>","2024-03-05",{"id":1220,"title":1221,"url":1222,"preview":1223,"target_date":1224,"picture":47},13892,"Enzymatic prodrug degradation in the fasted- and fed-state small intestine: In vitro studies and interindividual variability in human aspirates","enzymatic-prodrug-degradation-in-the-fasted-and-fed-small-intestine","\u003Cp>The aim of the current study was (1) to develop an automation-based protocol for in vitro assessment of enzymatic drug stability at fasted- and fed-state intestinal conditions, (2) to characterize the inter-individual variability of drug degradation in fasted- and fed-state human intestinal fluids, and (3) to compare the obtained in vitro results to drug degradation in human intestinal fluids by taking variability into account.\u003C/p>","2024-02-06",{"id":1226,"title":1227,"url":1228,"preview":1229,"target_date":1230,"picture":47},13890,"Algorithms for self-driving labs","algorithms-for-self-driving-labs","\u003Cp>This dissertation investigates how self-driving laboratories can be improved with the help of machine learning and data management techniques.\u003C/p>","2023-12-12",{"id":1232,"title":1233,"url":1234,"preview":1235,"target_date":1236,"picture":47},13888,"How technical innovations may help to prevent drug shortages in Switzerland","how-technical-innovations-may-help-to-prevent-drug-shortages-in-switzerland","\u003Cp>In this work, we investigated the technical feasibility of ‘on-demand’ production of selected drugs to cover their demand for a time window of 90 days.\u003C/p>","2023-12-04",{"id":1238,"title":1239,"url":1240,"preview":1241,"target_date":1242,"picture":47},13871,"Solid Dispensing Technologies for Microscale & Nanoscale Reaction Screening","solid-dispensing-microscale-nanoscale-reaction-screening","\u003Cp>The ability to rapidly examine diverse reaction conditions in parallel at micromole or nanomole scales without depleting precious starting materials is of critical importance to methodological development and reaction optimization.\u003C/p>","2023-10-03",{"id":1244,"title":1245,"url":1246,"preview":1247,"target_date":1248,"picture":47},13865,"Multistep automated synthesis of pharmaceuticals","multistep-automated-synthesis-of-pharmaceuticals","\u003Cp>Multistep automated pharmaceutical syntheses have been a long-term industrial goal. Automation not only enables the rapid and highly efficient preparation of organic compounds by eliminating the physical barriers, but also endow chemists with more time for critical thinking by relieving them from laborious work. With the growing demand for fast and efficient synthesis of active pharmaceutical ingredients (APIs) for drug development, several efforts have been made in various subfields to improve the universality and capability of automation in multistep synthesis.\u003C/p>","2023-06-22",{"id":1250,"title":1251,"url":1252,"preview":1253,"target_date":1254,"picture":47},13842,"Automated methods for ferrocene chemistry","automated-methods-for-ferrocene-chemistry","\u003Cp>Despite numerous technical advances over the last century, the field of academic organic chemistry still relies heavily on manual labor and non-systematic experiment design. \u003C/p>","2023-04-25",{"id":1256,"title":1257,"url":1258,"preview":1259,"target_date":1260,"picture":1261},13858,"Substrate specific closed-loop optimization of carbohydrate protective group chemistry using bayesian optimization and transfer learning","substrate-specific-closed-loop-optimization","\u003Cp>A new way of performing reaction optimization within carbohydrate chemistry is presented. \u003C/p>","2023-04-04","015a9d15-c91b-4ff0-8886-b17fa3215ce4",{"id":1263,"title":1264,"url":1265,"preview":1266,"target_date":1267,"picture":1268},13854,"Microparticles decorated with cell-instructive surface chemistries actively promote wound healing","microparticles-decorated-with-cell-instructive-surface-chemistries-actively-promote-wound-healing","\u003Cp>Wound healing is a complex biological process involving close crosstalk between various cell types.\u003C/p>","2023-02-07","42e481b8-212d-4cc1-ac55-d0fcea8d062b",{"id":1270,"title":1271,"url":1272,"preview":1273,"target_date":1274,"picture":1275},13840,"All-Aqueous, Surfactant-Free, and pH-Driven Nanoformulation Methods of Dual-Responsive Polymer Nanoparticles and their Potential use as Nanocarriers of pH-Sensitive Drugs","all-aqueous-surfactant-free-and-p-h-driven-nanoformulation-methods-of-dual-responsive-polymer-nanoparticles-and-their-potential-use-as-nanocarriers-of-p-h-sensitive-drugs","\u003Cp>Macro Molecular Bioscience\u003C/p>\n\u003Cp>All-aqueous, surfactant-free, and pH-driven nanoformulation methods to generate pH- and temperature-responsive polymer nanoparticles (NPs) are described.\u003C/p>","2023-01-31","d96c947c-7a54-45cd-86da-5df7ee0c7748",{"id":1277,"title":1278,"url":1279,"preview":1280,"target_date":1281,"picture":1282},13855,"Fully automated synthesis robot sets new record in stereospecific carbon–carbon bond formation","fully-automated-synthesis-robot-sets-new-record-in-stereospecific-carbon-carbon-bond-formation","\u003Cp>A totally automated synthesis that allows carbon chains to be grown one atom at a time with control of chain length and stereochemistry has been developed.\u003C/p>","2023-01-29","db03fc76-38b7-43c7-927b-613142eee40f",{"id":1284,"title":1285,"url":1286,"preview":1287,"target_date":1288,"picture":47},13838,"An automated, modular, chemistry robotics platform for rapid data generation and statistical model development","an-automated-modular-chemistry-robotics-platform-for-rapid-data-generation-and-statistical-model-development","\u003Cp>School of Chemistry, University of York\u003C/p>\n\u003Cp>Accelerating the throughput in addition to increasing the number of experiments is critical in research and development.\u003C/p>","2023-01-26",{"id":1290,"title":1291,"url":1292,"preview":1293,"target_date":1294,"picture":47},13843,"The development and applications of autonomous process optimization systems","the-development-and-applications-of-autonomous-process-optimization-systems","\u003Cp>Autonomous process optimization involves the human-intervention free search of an input parameter space in order to minimize or maximize output parameters of interest.\u003C/p>","2023-01-24",{"id":1296,"title":1297,"url":1298,"preview":1299,"target_date":1300,"picture":1301},13841,"Digital Transformation: Accelerating Small-Molecule Drug Discovery","digital-transformation-accelerating-small-molecule-drug-discovery","\u003Cp>Advancing digital transformation can significantly reduce R&D costs and shorten drug discovery timelines.\u003C/p>\n\u003Cp> \u003C/p>","2023-01-16","f480dd3b-1f7e-47ca-a8ae-7193ebc4eb55",{"id":1303,"title":1304,"url":1305,"preview":1306,"target_date":1307,"picture":1308},13835,"Automated Platform for the Synthesis of Heparan Sulfate Oligosaccharide Libraries for Decoding Glycosaminoglycan-Protein Interactions","automated-platform-for-the-synthesis-of-heparan-sulfate-oligosaccharide-libraries-for-decoding-glycosaminoglycan-protein-interactions","\u003Cp>Glycosaminoglycans (GAGs) are abundant, ubiquitous carbohydrates in biology, yet their structural complexity has limited an understanding of their biological roles and structure-function relationships. \u003C/p>","2023-01-04","6d632a92-5aa7-447e-9b10-c144213e55d5",{"id":1310,"title":1311,"url":1312,"preview":1313,"target_date":1314,"picture":47},13831,"Autonomous Chemical Experiments: Challenges and Perspectives on Establishing a Self-Driving Lab","autonomous-chemical-experiments-challenges-and-perspectives-on-establishing-a-self-driving-lab","\u003Cp>\u003Cspan style=\"font-family: Inter, -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', serif;\">We must accelerate the pace at which we make technological advancements to address climate change and disease risks worldwide. This swifter pace of discovery requires faster research and development cycles enabled by better integration between hypothesis generation, design, experimentation, and data analysis. Typical research cycles take months to years.\u003C/span>\u003C/p>","2022-11-08",{"id":1316,"title":1317,"url":1318,"preview":1319,"target_date":1320,"picture":1321},13830,"Deciphering Complexity in Pd–Catalyzed Cross-Couplings: Side-Product Profiling and Rich Data Analysis of Many Reaction Outcomes Reveals an Intricate Network of Catalytic Cycles ","deciphering-complexity-in-pd-catalyzed-cross-couplings-side-product-profiling-and-rich-data-analysis-of-many-reaction-outcomes-reveals-an-intricate-network-of-catalytic-cycles-","\u003Cp>In this paper we examine a highly complex Pd-catalyzed reaction system that can form many products – the reaction of two molecules of 2-bromo-N-phenylbenzamide, which affords \u003Cem>N\u003C/em>-phenyl phenanthridinone as the primary product. The reaction is accompanied by a plethora of side-products, formed through activation of multiple sites, including C-Br, C-C, C-N, C-H and N-H bonds.\u003C/p>","2022-10-11","8b71d0ea-089a-4612-ad5f-b61ff864dca4",{"id":1323,"title":1324,"url":1325,"preview":1326,"target_date":1327,"picture":47},13823,"Hier entsteht die Zukunft (The future is born here)","hier-entsteht-die-zukunft","\u003Cp>Blick - Besuch in der Forschungsanstalt IBM\u003C/p>\n\u003Cp>In Rüschlikon ZH könnte wirklich Gold sein, was glänzt. Ein Besuch bei brillanten jungen Wissenschaftlern, die an technologischen Lösungen für unzählige unserer Probleme arbeiten.\u003C/p>","2022-08-10",{"id":1329,"title":1330,"url":1331,"preview":1332,"target_date":1327,"picture":1333},13825,"GraphRXN: A Novel Representation for Reaction Prediction","graph-rxn-a-novel-representation-for-reaction-prediction","\u003Cp>Research Square\u003C/p>\n\u003Cp>In recent years, it has been seen that artificial intelligence (AI) starts to bring revolutionary changes to chemical synthesis.\u003C/p>","93f07882-b214-4146-a415-3183bd3df155",{"id":1335,"title":1336,"url":1337,"preview":1338,"target_date":1339,"picture":47},13817,"Complex Trait Analysis of Human Gut Microbiome-Active Traits in Sorghum bicolor: a new category of human health traits in food crops","complex-trait-analysis-of-human-gut-microbiome-active-traits-in-sorghum-bicolor-a-new-category-of-human-health-traits-in-food-crops","\u003Cp>Nature Portfolio Journal\u003C/p>\n\u003Cp>Several bioactive components of the human diet have major effects on composition and function of the gut microbiome, but no systematic framework exists for understanding variation in microbiome-active components amid the vast amount of genotypic and phenotypic variation within a given species of food crop. Capitalizing on a novel automated in vitro microbiome screening (AiMS) methodology to quantify human gut microbiome phenotypes after fermentation of grain from genetically diverse lines, we show how microbiome phenotypes can be used as quantitative traits for genetic analysis. \u003C/p>","2022-06-29",{"id":1341,"title":1342,"url":1343,"preview":1344,"target_date":1345,"picture":47},13816,"„Müssen in Europa die Ärmel hochkrempeln“","muessen-in-europa-die-aermel-hochkrempeln","\u003Cp>Wirtschaftsforum\u003C/p>\n\u003Cp>Die Zeiten, in denen in Laboren noch ausschließlich manuell gearbeitet wurde, sind lange vorbei. Mit innovativen Systemen zur Digitalisierung und Automatisierung sorgt die Chemspeed Technologies AG mit Sitz in Füllinsdorf, Schweiz, weltweit dafür, dass Forschung und Entwicklung sowie Qualitätskontrollen beschleunigt, standardisiert und digitalisiert vorangetrieben werden können. Die Einsatzgebiete ihrer Lösungen reichen von Life Science über die Materials Science bis zu Consumer Goods & Performance Materials.\u003C/p>","2022-06-07",{"id":1347,"title":1348,"url":1349,"preview":1350,"target_date":1351,"picture":47},13818,"Modern Machine Learning for Tackling Inverse Problems in Chemistry: Molecular Design to Realization","modern-machine-learning-for-tackling-inverse-problems-in-chemistry-molecular-design-to-realization","\u003Cp>Chemical Communications Journal\u003C/p>\n\u003Cp>The discovery of new molecules and materials helps expand the horizons of novel and innovative real-life applications. In the pursuit of finding molecules with desired properties, chemists have traditionally relied on experimentation and recently on combinatorial methods to generate new substances often complimented by computational methods. The sheer size of the chemical space makes it infeasible to search through all possible molecules exhaustively. This calls for fast and efficient methods to navigate the chemical space to find substances with desired properties. \u003C/p>","2022-04-27",{"id":1353,"title":1354,"url":1355,"preview":1356,"target_date":1357,"picture":1358},13815,"A modern tool to accelerate process development to match the customer’s timeline","a-modern-tool-to-accelerate-process-development-to-match-the-customer-s-timeline","\u003Cp>Procos S.p.A\u003Cstrong> \u003C/strong>\u003C/p>\n\u003Cp>It is no secret that within this highly competitive environment, among pharmaceutical companies that are constantly trying to reduce the time-to-market of New Chemical Entities (NCE’s), the speed of Process Development activities is one of the key factors of success.\u003C/p>","2022-04-05","a9bc268c-4c58-41ae-a3a1-ca44368a43a0",{"id":1360,"title":1361,"url":1362,"preview":1363,"target_date":1364,"picture":1365},13814,"Automated Stereocontrolled Assembly-Line Synthesis of Organic Molecules","automated-stereocontrolled-assembly-line-synthesis-of-organic-molecules","\u003Cp>School of Chemistry, University of Bristol\u003C/p>\n\u003Cp>Automation has fuelled dramatic advances in fields such as proteomics and genomics (e.g., in preparation of proteins and nucleic acids), enabling non-experts to prepare, test and analyse complex biological molecules.\u003C/p>","2022-03-22","ff949705-8bfa-43a8-986a-b7d46f97c385",{"id":1367,"title":1368,"url":1369,"preview":1370,"target_date":1371,"picture":47},13790,"Is a robot coming for your job?","is-a-robot-coming-for-your-job","\u003Cp>The rise of automation in the chemistry lab \u003C/p>\n\u003Cp>Since the beginning of the pandemic, automated chemistry has moved up the priority list for many companies, says Paul Whittles, sales director at Deepmatter, a Glasgow, UK, based company developing tools for automated chemistry.\u003C/p>","2022-03-02",{"id":1373,"title":1374,"url":1375,"preview":1376,"target_date":1377,"picture":1378},13805,"The lithiation-borylation reaction: in situ IR spectroscopy studies & automation on a batch platform","the-lithiation-borylation-reaction-in-situ","\u003Cp>EThOS\u003C/p>\n\u003Cp>The homologation of boronic esters using lithiated Hoppe-type diisopropylcarbamates and Beak-type 2,4,6-triisopropylbenzoate (TIB) esters represents an efficient process for the formation of carbon-carbon bonds in a highly stereoselective manner.\u003C/p>","2022-02-15","1561044f-05ea-4305-a89c-020f66af2f52",{"id":1380,"title":1381,"url":1382,"preview":1383,"target_date":1384,"picture":1385},13804,"IBM Expands AI-Driven Materials Discovery Capabilities, Signs New Industry Collaborations, Sandmeyer Award 2022","ibm-expands-ai-driven-materials-discovery-capabilities","\u003Cp>IBM RoboRXN, a cloud-based AI-automated lab, designed to enable a new era of fast-track molecular discovery, now supports proprietary datasets and green chemistry combined with Chemspeed's automated synthesis solutions.\u003C/p>\n\u003Ch3>Sandmeyer Award 2022\u003C/h3>\n\u003Cp>\u003Cstrong>\u003Cspan lang=\"EN-US\">RXN for Chemistry Project Team from IBM Research Zurich\u003C/span>\u003C/strong>, namely\u003Cbr />\u003Cem>Alain Vaucher, Daniel Probst, Philippe Schwaller, Theophile Gaudin, Teodoro Laino, Matteo Manica, Alessandra Toniato, Federico Zipoli, Antonio Cardinale, Alessandro Castrogiovanni, Heiko Wolf, Aleksandros Sobczyk, Joppe Geluykens\u003C/em>\u003Cbr />for their important scientific breakthrough in the digitalization of synthetic organic chemistry that helps to improve digital workflows with state-of-the-art machine learning technologies.\u003C/p>","2022-02-08","6448892a-8ad2-44ba-88e6-16d0b846f0d1",{"id":1387,"title":1388,"url":1389,"preview":1390,"target_date":1391,"picture":1392},13797,"Data-science driven autonomous process optimization","data-science-driven-autonomous-process-optimization","\u003Cp>ChemRxiv Journal\u003C/p>\n\u003Cp>Autonomous process optimization involves the human intervention-free exploration of a range of predefined process parameters in order to improve responses such as reaction yield and product selectivity. Utilizing off-the-shelf components, we developed a closed-loop system capable of carrying out parallel autonomous process optimization experiments in batch with significantly reduced cycle times. Upon implementation of our system in the autonomous optimization of a palladium-catalyzed stereoselective Suzuki-Miyaura coupling, we found that the definition of a set of meaningful, broad, and unbiased process parameters was the most critical aspect of a successful optimization. In addition, we found that categorical parameters such as phosphine ligand were vital to determining the reaction outcome. To date, categorical parameter selection has relied on chemical intuition, potentially introducing an element of bias into the experimental design. In seeking a systematic method for the selection of a diverse set of phosphine ligands fully representative of the chemical space, we developed a strategy that leveraged computed molecular descriptor clustering analysis. This strategy allowed for the successful autonomous optimization of a stereoselective Suzuki-Miyaura coupling between a vinyl sulfonate and an arylboronic acid to selectively generate the E-product isomer in high yield.\u003C/p>","2021-10-15","0fa858d7-7d60-44d3-9b4a-758fed86fcba",{"id":1394,"title":1395,"url":1396,"preview":1397,"target_date":1398,"picture":1399},13794,"Demonstrate how machine learning tools can aid development of formulation, analysis and manufacturing of pharmaceutical drug products","demonstrate-how-machine-learning-tools-can-aid-development-of-formulation-analysis-and-manufacturing-of-pharmaceutical-drug-products","\u003Cp>\u003Cem>Rolf Taaning, Development Specialist PhD, and Erik Skibsted, Principal Scientist PhD at Novo Nordisk Denmark\u003C/em>\u003C/p>\n\u003Cp>Novo Nordisk has initiated several optimisation projects using machine learning tools and robotics as alternatives to traditional design of experiments (DoE) methodologies and hands-on experiments.\u003C/p>","2021-10-02","2d87507c-4056-43c2-9ed3-744b59a30ad9",{"id":1401,"title":1402,"url":1403,"preview":1404,"target_date":1405,"picture":47},13771,"The lab of the future is now","the-lab-of-the-future-is-now","\u003Cp>Chemical and Engineering News\u003C/p>\n\u003Cp>Recent demonstrations of AI-directed automation may herald a new world for drug and materials discovery.\u003C/p>","2021-09-15",{"id":1407,"title":1408,"url":1409,"preview":1410,"target_date":1411,"picture":47},13792,"Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry","technological-innovations-in-photochemistry-for-organic-synthesis-flow-chemistry-high-throughput-experimentation-scale-up-and-photoelectrochemistry","\u003Cp>Chemical Reviews\u003C/p>\n\u003Cp>Photoinduced chemical transformations have received in recent years a tremendous amount of attention, providing a plethora of opportunities to synthetic organic chemists.\u003C/p>","2021-09-04",{"id":1413,"title":1414,"url":1415,"preview":1416,"target_date":1417,"picture":47},13789,"Asymmetric Dehydrative Allylation Using Soft Ruthenium and Hard Brønsted Acid Combined Catalyst","asymmetric-dehydrative-allylation-using-soft-ruthenium-and-hard-bronsted-acid-combined-catalyst","\u003Cp>The Chemical Record\u003C/p>\n\u003Cp>Asymmetric Pd-catalyzed Tsuji-Trost-type allylation is an important catalytic reaction toward chiral natural and unnatural product syntheses.\u003C/p>","2021-08-03",{"id":1419,"title":1420,"url":1421,"preview":1422,"target_date":1423,"picture":47},13770,"The big benefits of going small","the-big-benefits-of-going-small","\u003Cp>Two independent Novartis projects, Mic-Drop and MicroCycle, aim to revolutionize early drug discovery while also simultaneously reducing the environmental impact.\u003C/p>","2021-06-24",{"id":1425,"title":1426,"url":1427,"preview":1428,"target_date":1429,"picture":47},13785,"AI creates new molecules - IBM livestream at the shore of Zurich lake","ai-creates-new-molecules-ibm-livestream-at-the-shore-of-zurich-lake","\u003Cp>IBM shows how AI creates new molecules  at the shore of Zurich lake with integrated live stream to a Chemspeed FLEX AUTOPLANT\u003C/p>","2021-05-31",{"id":1431,"title":1432,"url":1433,"preview":1434,"target_date":1435,"picture":47},13769,"Photocatalytic dehydroxymethylative arylation by synergistic cerium and nickel catalysis","photocatalytic-dehydroxymethylative-arylation-by-synergistic-cerium-and-nickel-catalysis","\u003Cp>Journal of the American Chemical Society\u003C/p>\n\u003Cp>Under mild reaction conditions with inexpensive cerium and nickel catalysts, easily accessible free alcohols can now be utilized as operationally simple and robust carbon pronucleophiles in selective C(sp\u003Csup>3\u003C/sup>)–C(sp\u003Csup>2\u003C/sup>) cross-couplings.\u003C/p>","2021-05-03",{"id":1437,"title":1438,"url":1439,"preview":1440,"target_date":1435,"picture":47},13772,"A coumarin-based analogue of thiacetazone as dual covalent inhibitor and potential fluorescent label of HadA in mycobacterium tuberculosis","a-coumarin-based-analogue-of-thiacetazone-as-dual-covalent-inhibitor-and-potential-fluorescent-label-of-had-a-in-mycobacterium-tuberculosis","\u003Cp>ACS Infectious Diseases Journal\u003C/p>\n\u003Cp>A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials.\u003C/p>",{"id":1442,"title":1443,"url":1444,"preview":1445,"target_date":1446,"picture":47},13767,"Automation of synthesis in medicinal chemistry: progress and challenges","automation-of-synthesis-in-medicinal-chemistry-progress-and-challenges","\u003Cp>ACS Medicinal Chemistry Letters\u003Cbr />\u003Cbr />Since the 1990s, concerted attempts have been made to improve the efficiency of medicinal chemistry synthesis tasks using automation.\u003C/p>","2021-04-01",{"id":1448,"title":1449,"url":1450,"preview":1451,"target_date":1452,"picture":47},13762,"Kinetic investigations on homo- and co-polymerizations of pentafluorophenyl (meth)acrylates","kinetic-investigations-on-homo-and-co-polymerizations-of-pentafluorophenyl-meth-acrylates","\u003Cp>European Polymer Journal\u003Cbr />\u003Cbr />Pentafluorophenyl methacrylate (PFPMA) and pentafluorophenyl acrylate (PFPA) are frequently used monomers to produce advanced materials for biomedical applications via (co)polymerization reactions. This contribution reports kinetic investigations of the reversible addition fragmentation chain transfer (RAFT) copolymerization of PFPMA and methyl methacrylate (MMA) mediated by a dithiobenzoate chain transfer agent (CTA) at 70°C in dimethyl formamide (DMF). \u003C/p>","2021-02-20",{"id":1454,"title":1455,"url":1456,"preview":1457,"target_date":1458,"picture":47},13761,"Preparation of PDLLA and PLGA nanoparticles stabilized with PVA and a PVA-SDS mixture: Studies on particle size, degradation and drug release","preparation-of-pdlla-and-plga-nanoparticles-stabilized-with-pva-and-a-pva-sds-mixture-studies-on-particle-size-degradation-and-drug-release","\u003Cp>Journal of Drug Delivery Science and Technology\u003Cbr />\u003Cbr />The use of poly(vinyl alcohol) (PVA) and a PVA-sodium dodecyl sulfate mixture (PVA-SDS) for the  colloidal stabilization of poly(DL-lactide) (PDLLA) and poly(DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with paclitaxel (PTX) was investigated.\u003C/p>","2021-02-17",{"id":1460,"title":1461,"url":1462,"preview":1463,"target_date":1464,"picture":47},13760,"New pharmapolymers for innovative nanomedicine applications","new-pharmapolymers-for-innovative-nanomedicine-applications","\u003Cp>The Collaborative Research Centre PolyTarget is developing polymer-based, nanoparticulate carrier  materials for the targeted application of active pharmaceutical ingredients. In the foreground are  systems that are suitable for the treatment of diseases and syndromes whose morbidity is significantly  characterized by an inflammatory reaction. The collaborative research centre PolyTarget is funded by the  German Research Foundation (DFG). Spokesman ist Prof. Dr. Ulrich S. Schubert.\u003C/p>","2021-02-12",{"id":1466,"title":1388,"url":1467,"preview":1390,"target_date":1468,"picture":1392},11694,"data-science-driven-autonomous-process-optimization-2","2020-11-12",{"id":1470,"title":1471,"url":1472,"preview":1473,"target_date":1468,"picture":47},11695,"Data science-driven autonomous reaction optimization by UBC, Merck Co., Inc. and Chemspeed","data-science-driven-autonomous-reaction-optimization-by-ubc-merck-co-inc-and-chemspeed","\u003Cp>Data driven high-throughput experimentation is enabling accelerated screening within pharmaceutical companies. New data science tools combined with machine learning are being implemented to efficiently tackle multivariate reaction optimization challenges.\u003C/p>\n\u003Cp>Melodie Christensen, from Merck & Co., Inc., and UBC provide an overview of the use of automation in her Data Rich Experimentation (DRE) lab and her move towards autonomous reaction screening in conjunction with digitalization.\u003C/p>\n\u003Cp>Melodie is an Associate Principal Scientist, Merck & Co., Inc. and a Ph.D. student at the Department of Chemistry, the University of British Columbia.\u003C/p>\n\u003Cp>She has a proven track record in high-throughput experimentation platforms to support early and late stage pharmaceutical process development.\u003C/p>",{"id":1475,"title":1476,"url":1477,"preview":1478,"target_date":1479,"picture":47},11693,"Artificial Intelligence Driven Autonomous Lab by IBM & Chemspeed","artificial-intelligence-driven-autonomous-lab-by-ibm-chemspeed","\u003Cp>The IBM and Chemspeed collaboration opens doors for a new era in synthetic chemistry with wide implications for the pharmaceutical and chemical industry.\u003C/p>\r\n\u003Cp>Teodoro and his team push the boundaries of AI-driven lab-automation at IBM Research Europe and have successfully implemented predictive retro-synthesis in silico with the autonomous execution by a Chemspeed automated synthesis workstation.\u003C/p>\r\n\u003Cp>Teodoro provides an overview of the project and how digitalization will enable us to accelerate drug development.\u003C/p>\r\n\u003Cp>Teodoro is a Distinguished Research Scientist and Manager of the Future of Computing for Accelerated Discovery in the department of Cognitive Computing and Industry Solutions at the IBM Research Laboratory in Zurich.\u003C/p>","2020-09-10",{"id":1481,"title":1482,"url":1483,"preview":1484,"target_date":1485,"picture":47},11483,"Are You Ready… for faster acting insulin?","are-you-ready-for-faster-acting-insulin","\u003Cp>CSIRO RAMP / Stanford University\u003C/p>\r\n\u003Cp>The outcomes of a 2018 collaboration between the RAMP Centre and researchers from the Appel Group at Stanford University were recently published in Science Translational Medicine.\u003C/p>\r\n\u003Cp>Right now if you’re a Type I diabetic, you need to inject insulin at the appropriate time to process the glucose load from your food. Current products are slow to act, and have a residual release time in the body. That makes them inefficient, and inconvenient. The technology presented in this paper suggests a path towards new insulin formulations that are 1) fast acting, 2) have less residual time in the body, and 3) have a good “shelf life”. That means you could more reasonably inject your insulin at meal time (instead of 30-45 minutes ahead) for optimal effect. The result is better control of your blood sugar, and more convenience. CSIRO’s RAMP centre is proud to have made a contribution to this fantastic work by the Appel Group, and especially enjoyed hosting Anton A.A. Smith and Joseph L. Mann here in our Melbourne labs.\u003C/p>\r\n\u003Cp>Insulin has been used to treat diabetes for almost 100 years; yet, current rapid-acting insulin formulations do not act quickly enough to provide good control at mealtime. In the RAMP centre, we implement high-throughput, controlled, radical polymerization techniques to generate a large library of acrylamide carrier/dopant copolymer (AC/DC) excipients (a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization) designed to reduce insulin aggregation. Our top-performing AC/DC excipient candidate enabled the development of an ultrafast-absorbing insulin lispro (UFAL) formulation, which remains stable under stressed aging conditions for 25 hours, compared to 5 hours for commercial fast-acting insulin lispro formulations (Humalog). In a porcine animal model of insulin-deficient diabetes, UFAL exhibited peak action at 9 min, whereas commercial Humalog exhibited peak action at 25 min. These ultrafast kinetics make UFAL a promising candidate for improving glucose control and reducing burden for patients with diabetes.\u003C/p>\r\n\u003Cp>See video footage from the RAMP centre at about 1:50, where you’ll see CSIRO and Stanford researchers working with the Chemspeed SWING XL platform housed in our labs.\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.youtube.com/watch?time_continue=3&v=Lz6jnh3WHbE&feature=emb_logo\" target=\"_blank\" rel=\"noopener\">Ultrafast Insulin Formulation May Enable Faster Management of Blood Sugar in Diabetes\u003C/a>\u003C/p>","2020-08-21",{"id":1487,"title":1488,"url":1489,"preview":1490,"target_date":1491,"picture":47},11474,"Quasi-block copolymer design of quaternized derivatives of poly (2-(dimethylamino)ethyl methacrylate): Investigations on thermo-induced self-assembly","quasi-block-copolymer-design-of-quaternized-derivatives-of-poly-2-dimethylaminoethyl-methacrylate-investigations-on-thermo-induced-self-assembly","\u003Cp>European Polymer Journal\u003C/p>\r\n\u003Cp>We describe the sequential incorporation of the quaternized monomer N-(2-(Methacryloyloxy)ethyl)-N,N-dimethylheptan-1-ammonium (QDM) (from 1 up to 5 mol %) into 2-((dimethylamino)ethyl methacrylate) polymer chains (PDMAEMA), via reversible addition-fragmentation chain transfer (RAFT) technique, to yield quasi-block copolymers (PDMAEMA-qb-P(DMAEMA-co-QDM)) with modified hydrophilic nature and thermo-induced self-assembly properties in aqueous solutions. This chemical modification promotes the formation of metastable nanostructures in aqueous medium. The morphological transitions were investigated by means of atomic force microscopy (AFM), dynamic light scattering (DLS), rheology and turbidimetry. The results indicated that the obtained nanostructures were stabilized by associative and cationic interactions conveyed by the quaternized moieties within the polymer chains. The size of these nanostructures could be modified as a function of molar mass, copolymer composition and temperature. The method described denotes an interesting alternative to modify the thermo-induced self-assembly behavior of PDMAEMA based copolymers employing low amounts of quaternized moieties.\u003C/p>","2020-08-10",{"id":1493,"title":1494,"url":1495,"preview":1496,"target_date":1497,"picture":47},11473,"Artificial Intelligence and Augmented Intelligence for Automated Investigations for Scientific Discovery","arti-cial-intelligence-and-augmented-intelligence-for-automated-investigations-for-scienti-c-discovery-2","\u003Cp>March 09-11, 2020, Wotton-under-Edge UK - The meeting was organized by the Dial-a-Molecule, Directed Assembly, and AI3 Science Discovery Networks. Dial-a-Molecule’s vision is that in 20-40 years, scientists will be able to deliver any desired molecule within a timeframe useful to the end-user, using safe, economically viable and sustainable processes. Predicting the outcome of unknown reactions is a key challenge, and a key problem is lack of data, particularly on “failed” reactions. Synthesis must become a data-driven discipline.\u003C/p>\n\u003Cp>Contribution using Chemspeed’s ISYNTH digitalizing, standardizing, accelerating automated synthesis solution: \u003Cstrong>Encoding solvents and product outcomes to improve reaction prediction systems\u003C/strong> Dr. Ella M. Gale, University of Bristol\u003C/p>","2020-08-01",{"id":1499,"title":1500,"url":1501,"preview":1502,"target_date":1503,"picture":47},11108,"Automated solution-phase syntheses of alpha 1 → 2, 1 → 3 type rhamnans and rhamnan sulfate fragments","automated-solution-phase-syntheses-of-alpha-1-2-1-3-type-rhamnans-and-rhamnan-sulfate-fragments","\u003Cp>Carbohydrate Research Journal\u003C/p>\r\n\u003Cp>Rhamnan and rhamnan sulfate are naturally occurring carbohydrates that have important biological functions and possible therapeutic applications, but studies are limited to the microheterogeneous mixtures from natural sources. This work reports the first synthesis of any sulfated rhamnan fragments and successful automation of the process with a recently developed automated solution-phase approach using N-iodosuccinimide/trimethylsilyl triflate (NIS/TMSOTf) promotor and levulinoyl ester deprotection conditions. The automated solution-phase activation/deprotection approach was initially able to create alpha 1 → 2, 1 → 3 type rhamnan di- and trisaccharide in moderate yields. Once these targets were achieved, a process to use SO3•pyridine complex in DMF for sulfation compatible with an automated solution-phase liquid handling system was developed and successfully applied to carbohydrate sulfation to create two rhamnan sulfate fragments with differing monosulfation patterns.\u003C/p>\r\n\u003Cp> \u003C/p>","2020-01-22",{"id":1505,"title":1506,"url":1507,"preview":1508,"target_date":1509,"picture":47},11057,"AbbVie High Throughput Chemistry Group – Chemspeed's Gravimetric Solid Dispensing enables Reagent Coated Glass Beads for Nanomole Scale Reaction Screening (ChemBeads)","abbvie-high-throughput-chemistry-group-chemspeeds-gravimetric-solid-dispensing-enables-reagent-coated-glass-beads-for-nanomole-scale-reaction-screening-chembeads","\u003Cp>Watch this inspiring video:\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.youtube.com/watch?v=ycUSNcO0kho&t=9s\" target=\"_blank\" rel=\"noopener\">AbbVie High Throughput Chemistry Group – Chemspeed's Gravimetric Solid Dispensing\u003C/a>\u003C/p>\r\n\u003Cp>For more information about the solution applied:\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.chemspeed.com/video/flex-swile/\" target=\"_blank\" rel=\"noopener\">FLEX SWILE\u003C/a>\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.chemspeed.com/flex-powderdose/\" target=\"_blank\" rel=\"noopener\">FLEX POWDERDOSE\u003C/a>\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.chemspeed.com/isynth-reactscreen/\" target=\"_blank\" rel=\"noopener\">ISYNTH REACTSCREEN\u003C/a>\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.chemspeed.com/isynth-catscreen-96/\" target=\"_blank\" rel=\"noopener\">ISYNTH CATSCREEN\u003C/a>\u003C/p>\r\n\u003Cp>For details please contact \u003Ca href=\"mailto:chemspeed@chemspeed.com\" target=\"_blank\" rel=\"noopener\">chemspeed@chemspeed.com\u003C/a>\u003C/p>","2019-11-15",{"id":1511,"title":1512,"url":1513,"preview":1514,"target_date":1515,"picture":47},10980,"Acid-mediated N-iodosuccinimide-based thioglycoside activation for the automated solution-phase synthesis of α-1,2-linked-rhamnopyranosides","acid-mediated-n-iodosuccinimide-based-thioglycoside-activation-for-the-automated-solution-phase-synthesis-of-a-12-linked-rhamnopyranosides","\u003Cp>Pure and Applied Chemistry Journal\u003C/p>\r\n\u003Cp>Carbohydrate structures are often complex. Unfortunately, synthesis of the range of sugar combinations precludes the use of a single coupling protocol or set of reagents. Adapting known, reliable bench-chemistry reactions to work via automation will help forward the goal of synthesizing a broad range of glycans. Herein, the preparation of di- and tri-saccharides of alpha 1→2 rhamnan fragments is demonstrated using thioglycoside donors with the development for a solution-phase-based automation platform of commonly used activation conditions using \u003Cem>N\u003C/em>-iodosuccinimide (NIS) with trimethylsilyl triflate. Byproducts of the glycosylation reaction are shown to be compatible with hydrazine-based deprotection conditions, lending broader functionality to this method as only one fluorous-solid-phase extraction step per coupling/deprotection cycle is required.\u003C/p>","2019-10-08",{"id":1517,"title":1518,"url":1519,"preview":1520,"target_date":1521,"picture":47},10844,"Versatile Methods to Dispense Submilligram Quantities of Solids Using Chemical-Coated Beads for High-Throughput Experimentation","versatile-methods-to-dispense-submilligram-quantities-of-solids-using-chemical-coated-beads-for-high-throughput-experimentation","\u003Cp>Organic Process Research & Development Journal\u003C/p>\r\n\u003Cp>High-throughput experimentation is a technique for screening multiple reaction conditions in parallel at micro or nanoscale without depleting precious starting materials. However, assembling a comprehensive screening set often involves the distribution of large number of solid reagents with diverse physical properties in small quantities. Automated solid dispensing, especially at submilligram scale, has long been a challenge with no practical and reliable solutions. This paper describes the use of our newly developed chemical-coated beads technology to provide a universal approach to the solid handling problem. This technology, when combined with an automated solid dispensing platform or calibrated scoops, can dispense submilligram quantities of a variety of solids with efficiency and adequate accuracy.\u003C/p>","2019-09-03",{"id":1523,"title":1524,"url":1525,"preview":1526,"target_date":1527,"picture":47},10634,"Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazoles and Indolizine Containing Compounds Flagged against Anti-Targets","synthesis-in-silico-and-in-vitro-evaluation-of-anti-leishmanial-activity-of-oxadiazoles-and-indolizine-containing-compounds-flagged-against-anti-targets","\u003Cp>Molecules Journal\u003C/p>\r\n\u003Cp>Due to the lack of approved vaccines against human leishmaniasis and the limitations of the current chemotherapy inducing side effects and drug resistance, development of new, effective chemotherapeutic agents is essential. This study describes the synthesis of a series of novel oxadiazoles and indolizine-containing compounds. The compounds were screened in silico using an EIIP/AQVN filter followed by ligand-based virtual screening and molecular docking to parasite arginase. Top hits were further screened versus human arginase and finally against an anti-target battery to tag their possible interactions with proteins essential for the metabolism and clearance of many substances. Eight candidate compounds were selected for further experimental testing. The results show measurable in vitro anti-leishmanial activity for three compounds. One compound with an IC50 value of 2.18 µM on Leishmania donovani intramacrophage amastigotes is clearly better positioned than the others as an interesting molecular template for further development of new anti-leishmanial agents. \u003C/p>","2019-06-06",{"id":1529,"title":1530,"url":1531,"preview":1532,"target_date":1527,"picture":47},10715,"Sanofi R&D; High-Throughput Experimentation for Reaction Optimization in Medicinal Research","sanofi-rd-high-throughput-experimentation-for-reaction-optimization-in-medicinal-research","\u003Cp>Chilly-Mazarin, France\u003C/p>\r\n\u003Cp>Watch this inspiring video:\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.youtube.com/watch?v=06_oKuo-_yA\" target=\"_blank\" rel=\"noopener\">Sanofi - High-Throughput Experimentation\u003C/a> (courtesy of Sanofi)\u003C/p>\r\n\u003Cp> \u003C/p>\r\n\u003Cp>For more information about the solution applied:\u003C/p>\r\n\u003Cp>\u003Ca href=\"https://www.chemspeed.com/isynth-reactscreen/\" target=\"_blank\" rel=\"noopener\">ISYNTH REACTSCREEN\u003C/a>\u003C/p>\r\n\u003Cp> \u003C/p>\r\n\u003Cp>For details please contact \u003Ca href=\"mailto:chemspeed@chemspeed.com\" target=\"_blank\" rel=\"noopener\">chemspeed@chemspeed.com\u003C/a>\u003C/p>",{"id":1534,"title":1535,"url":1536,"preview":1537,"target_date":1538,"picture":47},10594,"Development of an Automated Kinetic Profiling System with Online HPLC for Reaction Optimization","development-of-an-automated-kinetic-profiling-system-with-online-hplc-for-reaction-optimization","\u003Cp>The Royal Society of Chemistry Journal\u003C/p>\r\n\u003Cp>Automated kinetic profiling is a valuable tool for providing insights into key mechanistic features of complex catalytic systems. In an attempt to optimize a palladium-catalyzed Suzuki cross-coupling reaction, automated kinetic profiling was utilized with offline liquid chromatography to monitor reaction progress. Upon uncovering analytical sample instability issues, an online HPLC capability was developed and implemented through integration of a Chemspeed liquid handling robot with an Agilent HPLC to facilitate automated reaction set-up and monitoring. Application of this capability resulted in the observation that precatalyst activation was a key factor influencing the reaction rate. Leveraging this mechanistic insight, a more efficient method to access the active catalyst was developed. This change resulted in a five-fold increase in the reaction rate.\u003C/p>","2019-05-06",{"id":1540,"title":1541,"url":1542,"preview":1543,"target_date":1544,"picture":47},10593,"High Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads","high-throughput-reaction-screening-with-nanomoles-of-solid-reagents-coated-on-glass-beads","\u003Cp>Angewandte Chemie Journal\u003C/p>\r\n\u003Cp>Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents on micro- and nanomole scale prevents the full utilization of reaction screening technologies. We herein report the development of a technology in which glass beads coated with solid chemical reagents (ChemBeads) enable the delivery of nanomole quantities of solid chemical reagents efficiently. By exploring the concept of preferred screening sets, the flexibility and generality of this technology for high throughput reaction screening was validated.\u003C/p>","2019-05-01",{"id":1546,"title":1547,"url":1548,"preview":1549,"target_date":1550,"picture":47},10419,"Living in the Fast Lane; High Throughput Controlled/Living Radical Polymerization","living-in-the-fast-lane-high-throughput-controlled-living-radical-polymerization","\u003Cp>Macromolecules Journal\u003C/p>\r\n\u003Cp>Combinatorial and high throughput (HTP) methodologies have long been used by the pharmaceutical industry to accelerate the rate of drug discovery. HTP techniques can also be applied in polymer chemistry to more efficiently elucidate structure–property relationships, to increase the speed of new material development, and to rapidly optimize polymerization conditions. Controlled living/radical polymerization (CLRP) is widely employed in the preparation of potential materials for bioapplications being suitable for a large variety of polymeric materials with various architectures. The versatility of CLRP makes it an ideal candidate for combinatorial and HTP approaches to research, and recently, the development of oxygen tolerant CLRP techniques has greatly simplified the methodology. In this Perspective, we provide an overview of conventional CLRP, including automated parallel synthesizers, as well as oxygen tolerant CLRP applications for HTP polymer research.\u003C/p>","2019-03-01",{"id":1552,"title":1553,"url":1554,"preview":1555,"target_date":1550,"picture":47},10527,"An automated platform for the enzyme-mediated assembly of complex oligosaccharides","an-automated-platform-for-the-enzyme-mediated-assembly-of-complex-oligosaccharides","\u003Cp>University of Georgia\u003C/p>\n\u003Cp>Nature Chemistry Journal\u003C/p>\n\u003Cp>An automated platform that can synthesize a wide range of complex carbohydrates will greatly increase their accessibility and should facilitate progress in glycoscience. Here we report a fully automated process for enzyme-mediated oligosaccharide synthesis that can give easy access to different classes of complex glycans including poly-N-acetyllactosamine derivatives, human milk oligosaccharides, gangliosides and N-glycans. Our automated platform uses a catch and release approach in which glycos-yltransferase-catalysed reactions are performed in solution and product purification is accomplished by solid phase extraction. We developed a sulfonate tag that can easily be installed and enables highly efficient solid phase extraction and product release using a single set of washing conditions, regardless of the complexity of the glycan. Using this custom-built synthesizer, as many as 15 reaction cycles can be performed in an automated fashion without a need for lyophilization or buffer exchange steps.\u003C/p>",{"id":1557,"title":1558,"url":1559,"preview":1560,"target_date":1561,"picture":47},9845,"The Nebraska Food for Health Center chooses Chemspeed FLEX POWDERDOSE for their plant material research","the-nebraska-food-for-health-center-chooses-chemspeed-flex-powderdose-for-their-plant-material-research","\u003Cp>July 2018 - Nebraska, USA \u003C/p>\r\n\u003Cp>Director of the Nebraska Food for Health Center states, “Our lab is screening 100’s of thousands of plant materials which requires repetitive, accurate dispensing of solids. Done manually, this work is tedious and prone to errors. After extensive research, we determined that Chemspeed’s FLEX POWDERDOSE was the only product available to provide accurate and reproducible “many to many” dispensing.”\u003C/p>","2018-07-31",{"id":1563,"title":1564,"url":1565,"preview":1566,"target_date":1561,"picture":47},9847,"Tailoring Cellular Uptake of Gold Nanoparticles Via the Hydrophilic-to-Hydrophobic Ratio of their (Co)polymer Coating","tailoring-cellular-uptake-of-gold-nanoparticles-via-the-hydrophilic-to-hydrophobic-ratio-of-their-copolymer-coating","\u003Cp>Ghent University, Belgium\u003C/p>\r\n\u003Cp>Advanced Functional Materials Journal\u003C/p>\r\n\u003Cp>It is demonstrated how cellular uptake and protein corona of (co)polymer-coated gold nanoparticles can be altered by the hydrophilic-to-hydrophobic comonomer ratio. A novel, label-free flow cytometry strategy is developed to investigate particle uptake. These findings offer insight in the design and analysis of hybrid nanomaterials for interfacing with biological systems.\u003C/p>",{"id":1568,"title":1569,"url":1570,"preview":1571,"target_date":1572,"picture":47},9788,"Chemspeed’s SWILE enables Bayer’s Production of Screening Kits","chemspeeds-swile-enables-bayers-production-of-screening-kits","\u003Cp>June 2018\u003C/p>\r\n\u003Cp>”We are using our Chemspeed SWILE Catalyst Dispensing solution for the production of screening kits for cross coupling reaction such as Suzuki or Buchwald reactions. The system took over all our manual and tedious weighing tasks of small quantities between 1 and 3.5 mg. It produces reaction kits for screening reactions in 96-well format which can be used in our fully automated ISYNTH screening platform.”\u003C/p>","2018-06-20",{"id":1574,"title":1575,"url":1576,"preview":1577,"target_date":1578,"picture":47},9818,"The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis","the-evolution-of-chemical-high-throughput-experimentation-to-address-challenging-problems-in-pharmaceutical-synthesis","\u003Cp>The structural complexity of pharmaceuticals presents a significant challenge to modern catalysis. The use of high-throughput experimentation (HTE) techniques offers a means to overcome this fundamental challenge...\u003C/p>","2018-05-01",{"id":1580,"title":1581,"url":1582,"preview":1583,"target_date":1584,"picture":47},8275,"Selective functionalization of complex heterocycles via an automated strong base screening platform","selective-functionalization-complex-heterocycles-via-automated-strong-base-screening-platform","\u003Cp>August 2017, Merck & Co., Inc., Rahway, NJ, USA\u003C/p>\n\u003Cp>Reaction Chemistry & Engineering, The Royal Society of Chemistry\u003C/p>\n\u003Cp>Knochel – Hauser bases, derived from 2,2,6,6-tetramethylpiperidinyl (TMP) metal amides, offer exceptional selectivity and functional group tolerance in the regioselective metalation of arenes and heteroarenes. The selectivity, stability and yield of these reactions are highly dependent on the nature of the base, additive and deprotonation temperature.\u003C/p>","2017-08-07",{"id":1586,"title":1587,"url":1588,"preview":1589,"target_date":1590,"picture":47},7602,"Dual pH and ultrasound responsive nanoparticles with pH triggered surface charge-conversional properties","dual-ph-and-ultrasound-responsive-nanoparticles-with-ph-triggered-surface-charge-conversional-properties","A series of dual pH- and ultrasound responsive statistical copolymers were synthesized via the reversible addition–fragmentation chain transfer (RAFT) polymerization of 3,4-dihydro-2H-pyran (DHP) protected HEMA 2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl methacrylate (THP-HEMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA)","2017-06-20",{"id":1592,"title":1593,"url":1594,"preview":1595,"target_date":1596,"picture":47},6327,"Effect of the Degree of Quaternization and Molar Mass on the Cloud Point of Poly [2-(dimethylamino) ethyl methacrylate] Aqueous Solutions: A Systematic Investigation","effect-of-the-degree-of-quaternization-and-molar-mass-on-the-cloud-point-of-poly-2-dimethylamino-ethyl-methacrylate-aqueous-solutions-a-systematic-investigation","A systematic investigation to fine-tune the cloud point of thermoresponsive poly [2-(dimethylamino)ethyl methacrylate) (p(DMAEMA)) aqueous solutions in a broad temperature interval is reported. For this research, p(DMAEMA)s of different molar mass are quaternized at distinct degrees with methyl iodide to obtain an expanded library of poly[DMAEMA-copoly[ 2-(methacryloyloxy) ethyl] trimethylammonium iodide]s","2017-06-15",{"id":1598,"title":1599,"url":1600,"preview":1601,"target_date":1602,"picture":47},6993,"Palladium-Catalyzed Direct α-Arylation of p-Methoxybenzyl-Protected S,S-Dimethylsulfoximine","palladium-catalyzed-direct-a-arylation-of-p-methoxybenzyl-protected-ss-dimethylsulfoximine","\u003Cspan lang=\"EN-GB\">Sulfoximines have recently gained considerable recognition as an important structural motif in the life sciences\u003C/span>","2017-02-23",{"id":1604,"title":1605,"url":1606,"preview":1607,"target_date":1608,"picture":47},6558,"Synthesis of Novel Bromodifluoromethyl(arylsulfonyl) Compounds and Nickel Catalyzed Cross Coupling with Arylboronic Acids","synthesis-novel-bromodifluoromethylarylsulfonyl-compounds-nickel-catalyzed-cross-coupling-arylboronic-acids","A nickel catalyzed Suzuki coupling of arylboronic acids and novel bromodifluoromethyl(arylsulfonyl)\r\ncompounds is described, providing an example of direct Csp2-CF2SO2Ar bond formation","2016-07-07",{"id":1610,"title":1611,"url":1612,"preview":1613,"target_date":1614,"picture":47},6438,"First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates","first-catalytic-asymmetric-hydrogenation-quinoxaline-2-carboxylates","For the first time, the asymmetric hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands","2016-05-03",{"id":1616,"title":1617,"url":1618,"preview":1619,"target_date":1620,"picture":47},6339,"Automated Sample Preparation for Content Uniformity Tests of Tablets","automated-sample-preparation-content-uniformity-tests-tablets","\u003Cem>Develco Pharma Schweiz AG successfully implemented an automated sample preparation system for content uniformity tests of tablets.\u003C/em>","2016-02-01",{"id":1622,"title":1623,"url":1624,"preview":1625,"target_date":1626,"picture":47},6087,"Catalyst for Efficient Cleavage of Allyloxy Bonds","catalyst-for-efficient-cleavage-of-allyloxy-bonds","\u003Cem>2014 Tetrahedron Prize for Creativity in Organic Chemistry, Palladium and Other Transition Metal-Catalyzed Reactions: Invention and Applications\r\n\u003C/em>\u003Cem>Soft ruthenium and hard Brønsted acid combined catalyst for efficient cleavage of allyloxy bonds\u003C/em>","2015-08-19",{"id":1628,"title":1629,"url":1630,"preview":1631,"target_date":1632,"picture":47},2625,"Protecting-Group-Free Solid-Phase Anchoring of Polyphenolic C-Glucosidic Ellagitannins and Synthesis of 1-Alkylamino-Vescalagin Derivatives with Chemspeed’s Fully Automated SYNTHESIZER","protecting-group-free-solid-phase-anchoring-polyphenolic-c-glucosidic-ellagitannins-synthesis-1-alkylamino-vescalagin-derivatives-chemspeeds-fully-automated-synthesizer","The C-glucosidic ellagitannins vescalagin and vescalin are among the plant polyphenols that have been shown to interact with protein targets in a specific manner","2014-09-01",{"id":1634,"title":1635,"url":1636,"preview":1637,"target_date":1632,"picture":47},2628,"Extraction, Identification and Enzymatic Synthesis of Acylated Derivatives of Anthocyanins from Jaboticaba (Myrciaria Cauliflora) Fruits with Chemspeed’s Fully Automated SYNTHESIZER","extraction-identification-enzymatic-synthesis-acylated-derivatives-anthocyanins-jaboticaba-myrciaria-cauliflora-fruits-chemspeeds-fully-automated-synthesizer","Polyphenols were extracted from the skin of jabuticaba fruits (Myrciaria cauliflora). Their total concentration and in vitro antioxidant activity were analysed by the DPPH and ABTS methods. The corresponding results (dry basis) were 1290 mg gallic acid equivalent (GAE)∙(100 g)-¹, 98% of DPPH radical inhibition and 120 µM TEAC∙g-¹ (ABTS method)",{"id":1639,"title":1640,"url":1641,"preview":1642,"target_date":1643,"picture":47},1448,"CSIRO Australia Reports on the Enabling Synthesis of Cubosomes with Chemspeed’s Fully Automated SYNTHESIZER","csiro-australia-reports-on-the-enabling-synthesis-of-cubosomes-with-chemspeeds-fully-automated-synthesizer","For Advancing the Development of Novel Materials CSIRO and Chemspeed have successfully implemented since July 2009 the SYNTHESIZER robotic platform and extended capacity and capabilities in December 2013 with the acquisition of another SYNTHESIZER robotic platform.","2014-03-03",{"id":1645,"title":1646,"url":1647,"preview":1648,"target_date":1643,"picture":47},1450,"Automated Content Uniformity Test successfully implemented at KLOSTERFRAU Berlin","automated-content-uniformity-test-successfully-implemented-at-klosterfrau-berlin","The KLOSTERFRAU Health Care Group efficiently implemented the automation of sample preparation and analysis for more than two years",{"id":1650,"title":1651,"url":1652,"preview":1653,"target_date":1654,"picture":47},1443,"Chemspeed releases New AutoSuite Software 2.0","chemspeed-releases-new-autosuite-software-2-0","Chemspeed Technologies has released its latest version of the AutoSuite Software. This new version offers \u003Cstrong>full support for Windows 7 (32 and 64 bit)\u003C/strong> and a number of new capabilities and improvements among which:","2014-02-03",{"id":1656,"title":1657,"url":1658,"preview":1659,"target_date":1660,"picture":47},1441,"Chemspeed introduces its Fully Automated Parallel / Multi-Channel pH Measurement tool","chemspeed-introduces-its-fully-automated-parallel-multi-channel-ph-measurement-tool","Chemspeed is pleased to have introduced its Fully Automated Parallel / Multi-Channel pH Measurement and Adjustment Tool compliant with its sample preparation (SWING), synthesis (ISYNTH), process research (AUTOPLANT), and formulation (EMULSIFIER, FORMAX) product lines.","2014-01-06",{"id":1662,"title":1663,"url":1664,"preview":1665,"target_date":1666,"picture":47},1128,"ISYNTH - Next Generation of Chemspeed’s Unique, Proprietary Array Synthesis Reactor Technology","isynth-next-generation-of-chemspeeds-unique-proprietary-array-synthesis-reactor-technology","Chemspeed is pleased to have introduced its ISYNTH robotic workstation, moving its renowned array reactor technology to the next level of ease-of-use for library syntheses.","2013-10-10",{"id":1668,"title":1669,"url":1670,"preview":1671,"target_date":1672,"picture":47},1111,"Automated Click Chemistry – Synthesis of a Triazole Library","automated-click-chemistry-synthesis-of-a-triazole-library","PharmBioTec have chosen Chemspeed Technologies as their partner for automating their synthetic drug discovery program","2013-08-10",{"id":1674,"title":1675,"url":1676,"preview":1677,"target_date":1678,"picture":47},1093,"SP Process Development AB Boosts Its Catalyst Screening with Chemspeed's CATSCREEN 96","sp-process-development-ab-boosts-its-catalyst-screening-with-chemspeeds-catscreen-96","\"The Chemspeed CATSCREEN 96 is a real workhorse with a capacity to run many hundreds of reactions per week","2013-06-10",{"id":1680,"title":1681,"url":1682,"preview":1683,"target_date":1684,"picture":47},1083,"Genetic Engineering & Biotechnology News - Chemspeed’s Numerous Disruptive Technologies in Laboratory Automation Workflows Spark Creativity","genetic-engineering-biotechnology-news-chemspeeds-numerous-disruptive-technologies-in-laboratory-automation-workflows-spark-creativity","To highlight the importance of Chemspeed’s unrivalled innovations, Dr. Michael Schneider, Sr VP Business Development, gave an interview to Genetic Engineering & Biotechnologies News about Lab Automation Sparking Creativity:","2013-04-10",{"id":1686,"title":1687,"url":1688,"preview":1689,"target_date":1690,"picture":47},1072,"Advancing the Development of Novel Materials using Chemspeed’s Fully Automated SYNTHESIZER","advancing-the-development-of-novel-materials-using-chemspeeds-fully-automated-synthesizer","CSIRO and Chemspeed have successfully implemented since July 2009 the SYNTHESIZER robotic platform with nine automated tools using Chemspeed’s unique robotic tool exchange technology","2013-02-10",{"id":1692,"title":1693,"url":1694,"preview":1695,"target_date":1696,"picture":47},1785,"ITAV and Chemspeed Technologies lead a successful partnership","itav-chemspeed-technologies-lead-successful-partnership","\u003Cstrong>For the 5th successive year, Institut des Technologies Avancées en sciences du Vivant (ITAV), part of the Oncopole in Toulouse, and Chemspeed Technologies lead a successful partnership\u003C/strong>","2012-11-11",{"id":1698,"title":1699,"url":1700,"preview":1699,"target_date":1701,"picture":47},1782,"Klosterfrau implements fully automated content uniformity testing","klosterfrau-implements-fully-automated-content-uniformity-testing","2012-11-07",{"id":1703,"title":1704,"url":1705,"preview":1706,"target_date":1707,"picture":47},1788,"Chemspeed Technologies and University of York Chemistry Department  Announce Partnership for Synthesis and Catalysis Development","chemspeed-technologies-university-york-chemistry-department-announce-partnership-synthesis-catalysis-development","\u003Cstrong>Accelerating the speed and increasing the number of experiments is a critical factor in research and development.\u003C/strong>","2012-10-07",{"id":1709,"title":1710,"url":1711,"preview":1712,"target_date":1707,"picture":47},1792,"Accelerating the Process of Drug Discovery – Chemspeed makes it  possible","accelerating-process-drug-discovery-chemspeed-makes-possible","\u003Cstrong>PharmBioTec’s department of Drug Discovery focuses on the synthesis of small, drug-like molecules for a broad range of therapeutic targets\u003C/strong>",{"id":1714,"title":1715,"url":1716,"preview":1717,"target_date":1718,"picture":47},1805,"New algorithm for non-flowable powders","new-algorithm-non-flowable-powders","Chemspeed broadens the field of application of its solid dispensing technology with a new algorithm for non-flowable powders.","2012-04-07",{"id":1720,"title":1721,"url":1722,"preview":1723,"target_date":1724,"picture":47},1815,"The Discovery of an Amino C-H Arylation Reaction","discovery-amino-c-h-arylation-reaction","The MacMillan group, at the University of Princeton USA, recently reported in Science, the “Discovery of an a-Amino C–H Arylation Reaction Using the Strategy of Accelerated Serendipity” with Chemspeed’s SYNTHESIZER technology.","2012-03-07",{"id":1726,"title":1727,"url":1728,"preview":1729,"target_date":1730,"picture":47},1824,"Chemspeed celebrates its 10th anniversary with Bayer HealthCare","chemspeed-celebrates-10th-anniversary-bayer-healthcare","Chemspeed recently celebrated 10 full operating years with Bayer HealthCare Pharmaceuticals (Bayer) in Berlin, Germany it runs five Chemspeed instruments in its laboratories. Building on the instrument reliability, Bayer is now moving to the next generation of Chemspeed’s equipment.","2012-01-07",{"id":1732,"title":1733,"url":1734,"preview":1735,"target_date":1736,"picture":47},1841,"Chemspeed Synthesizer Biomat Platform helps CSIRO's research on Drug Delivery Systems","chemspeed-synthesizer-biomat-platform-helps-csiros-research-drug-delivery-systems","\u003Cstrong>Chemspeed SYNTHESIZER BIOMAT Platform helps CSIRO’s research on Drug Delivery Systems as illustrated in recent article in International Journal of Pharmaceutics\u003C/strong>","2011-08-07",{"id":1738,"title":1739,"url":1740,"preview":1741,"target_date":1736,"picture":47},1838,"Chemspeed Catalyst Screening Solution has 6 months ROI at  AstraZeneca","chemspeed-catalyst-screening-solution-6-months-roi-astrazeneca","Catalyst screening is both a nightmare and the Holy Grail in selective synthesis. Companies like AstraZeneca have understood it very well. It is a nightmare because it is very difficult to predict which catalyst-ligand-solvent-additive combination and which conditions will lead to the best results",{"id":1743,"title":1744,"url":1745,"preview":1746,"target_date":1747,"picture":47},1853,"Further patent granted for breakthrough dispensing technology concept","patent-granted-breakthrough-dispensing-technology-concept","Chemspeed was recently granted a patent on Overhead Gravimetric Dispensing Technology, despite challenges from other market players","2011-05-07",1781171696406]