ISYNTH for versatile synthesis

High throughput library synthesis of organics, inorganics, and hybrid materials in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors with mixing, heating, refluxing, cooling, vacuum, inert gas.

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Overview

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our disposable or reusable or microwave or photochemistry or pressure reactors and our user-friendly software enable you to accelerate, standardize and digitalize your parallel, automated synthesis workflows such as:

Organic syntheses
Reaction screening
Photochemistry
Ligand syntheses
Organometallic syntheses
Living / controlled polymerizations
Nanomaterials syntheses
Impregnations
Biomass pretreatment and conversion
C-X Coupling, hydrogenation, hydroformylation, carbonylation, metathesis, oxidation, … screenings
Polyolefin solution- & slurry-phase screenings

Workflow

ISYNTH

Migrated workflow: ISYNTH

Benefits

Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis as well as reaction screening.
Easy-to-use disposable multi-functional, high-precision glass reactor arrays, available reaction scales from μL to mL.
Glass reactor arrays with screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C / -70°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
Proprietary robotic tool exchange.
Gravimetric solid handling from μg to g.
Gravimetric liquid handling from mg to g / μL to mL.
Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry (optional integration within customized MBraun glove-box).
AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.