Automated, parallel library synthesis of e.g. organics, inorganics, nanomateriales

ISYNTH for versatile synthesis

High throughput library synthesis of organics, inorganics, and hybrid materials in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors with mixing, heating, refluxing, cooling, vacuum, inert gas.

Overview

Chemspeed's solution

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our disposable or reusable or microwave or photochemistry or pressure reactors and our user-friendly software enable you to accelerate, standardize and digitalize your parallel, automated synthesis workflows such as:

Organic syntheses
Reaction screening
Photochemistry
Ligand syntheses
Organometallic syntheses
Living / controlled polymerizations
Nanomaterials syntheses
Impregnations
Biomass pretreatment and conversion
C-X Coupling, hydrogenation, hydroformylation, carbonylation, metathesis, oxidation, … screenings
Polyolefin solution- & slurry-phase screenings

Two Chemspeed Swing platforms with raised cantelever doors housing multiple analytic and mixing tools for a laboratory

Workflow

Example workflow

The interactive workflow panel below showcases example workflows for this solution. Each Chemspeed tool or module performs a set of specific actions, as in any manual lab workflow, and an almost limitless arrangement of these tools is possible.

ISYNTH

Benefits

Powerful advantages

Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis as well as reaction screening.
Easy-to-use disposable multi-functional, high-precision glass reactor arrays, available reaction scales from μL to mL.
Glass reactor arrays with screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C / -70°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
Proprietary robotic tool exchange.
Gravimetric solid handling from μg to g.
Gravimetric liquid handling from mg to g / μL to mL.
Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry (optional integration within customized MBraun glove-box).
AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.

Software

AUTOSUITE

Chemspeed’s AUTOSUITE software packages execute and control all modules in every solution. They control all Chemspeed robotic platforms and any other integrated 3^rd-party software and hardware.

Explore AUTOSUITE

Chemspeed AutoSuite Software laptop screen