example solution
Flex

End-to-end NMR and LCMS sample preparation

FLEX SWILE NMR
Overview

Chemspeed's solution

Nuclear magnetic resonance (NMR) is a method of physical observation in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field and therefore not involving electromagnetic waves) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. 

NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics, crystals as well as non-crystalline materials. NMR is also routinely used in advanced medical imaging techniques, such as in magnetic resonance imaging (MRI).

However, the preparation of NMR samples is often still done manually and binds highly qualified resources to very time-consuming, tedious and error-prone tasks.

The SWILE technology enables automated true one-to-one gravimetric "pick & decision dispense" of solid compounds. The scheme at the bottom of this page displays the simplified SWILE workflow including the precision "pick & decision dispense" step. The technology backbone is based on Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.

In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by the automated SWIN dispenser. The SWINs are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used to loosening up and tilting the powder prior to pick-up.

  • Revolutionary accuracy & precision due to decision dispensing
  • Dispensing range from <100 μg to about 5 mg with +/- 10 μg resolution
  • No cross-contamination
  • No dead volume
  • Unattended operation
  • Fully inert (glass)

Workflow

Example workflow

FLEX SWILE NMR

Benefits

Powerful advantages

  • Proprietary robotic tool exchange interface.
  • Ventilated hood for safety and trolley.
  • Optimized footprint (3x3 ft, 90x90 cm) versus capacity - all while reducing costs and maximizing return on investment.
  • SWILE Robotic Tool can be combined with other tools to accommodate multiple workflows.
  • On-deck balance, tilt / shake rack, barcode reader, multigripper.
  • Automated sample dispensing into NMR tubes and LC vials (optional on-deck balance for +/- 10 μg resolution).
  • Gravimetric and volumetric liquid handling for e.g. dissolution.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface to data analysis.
  • Interface for e.g. LIMS, ELN integration.
Software
Chemspeed AutoSuite Software laptop screen