FLEX SWILE for NMR LCMS Sample Prep

Step-change in end-to-end NMR and LCMS sample preparation - gravimetric pick & decision dispense of solids / matrix-to-matrix reformatting, dissolution and online / offline NMR and / or LC-MS (incl. applications in GMP environments).

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Overview

The preparation of NMR and / or LC-MS samples is often still done manually and binds highly qualified resources to very time-consuming, tedious and error-prone tasks.

The SWILE technology enables automated true one-to-one gravimetric "pick & decision dispense" of solid compounds directly from sour vials. The scheme at the bottom of this page displays the simplified SWILE workflow including the precision "pick & decision dispense" step. The technology backbone is based on Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.

In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by the automated SWIN dispenser. The SWINs are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used to loosening up and tilting the powder prior to pick-up.

Revolutionary accuracy & precision due to decision dispensing
Dispensing range from 100’s μg to about 5 mg with +/- 10 μg resolution with additional on-deck balance
No cross-contamination
No dead volume
Fully inert (glass)
Unattended operation

Workflow

FLEX SWILE NMR

Migrated workflow: FLEX SWILE NMR

Benefits

Proprietary robotic tool exchange interface.
Ventilated hood for safety and conditioned atmosphere.
Optimized footprint (3x3 ft, 90x90 cm) versus capacity - all while reducing costs and maximizing return on investment.
SWILE Robotic Tool can be combined with other tools to accommodate multiple workflows such as on-deck balance, tilt / shake rack, barcode reader, multigripper.
Automated sample dispensing into NMR tubes and LC vials (optional on-deck balance for +/- 10 μg resolution).
Gravimetric and / or volumetric liquid handling for e.g. dissolution combined with e.g. tumble stirrer, shaking modules.
AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, Bruker sample case, Agilent / Shimadzu / Thermo / Waters autosamplers.