Automated process R&D and preparative synthesis

Each reactor with its own set of conditions - individually controlled tank reactors (reactor volumes 100, 240, 1’000 mL total volume) with precise, continuous feeds.

• Up to 6 syntheses per run on a FLEX AUTOPLANT (incl reaction prep, reaction execution, work-up, analysis).
• Easily exchangeable stirrer designs (anchor, twisted blade, gas entrainment stirrers…).
• Powerful mixing for viscosities up to 80 Pa.s at 300 rpm and 30 Pa.s at 900 rpm with an anchor stirrer.
• Flexible and precise continuous feeds.
• Multiple continuous liquid, liquefied gas and / or gas feeds per reactor and additional unlimited overhead access.
• Internal and / or jacket temperature control, reflux.
• Pressure up to 100 bar with corresponding safety installations.
• Parallel high-performance calorimetry and viscosity data.
• PAT interfaces to various in-situ probes, for example: pH, UV-VIS, IR, Raman, PSD, calorimetry.
• Measurement of gas consumption.
• Dean Stark water trap.
• Distillation bridge.
• Vacuum for different purposes: inertization, crystallization, ...
• Extraction, filtration, evaporation, crystallization, distillation.
• Ventilated hood for safety and conditioned (sensitive chemicals, low-temperature) operation.
• AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
• Optional integrated online benchtop NMR with available operating frequency ranges of e.g. 80 / 90 MHz such as Bruker Fourier Rxn Lite, Magritek Spinsolve, incl. NMR device, sample injection port, software and hardware integration, H / F / C / P / Si / B, 1D and 2D spectra, online data acquisition via flow cell or offline via standard 5 mm sample tubes, permanent magnet - no liquid nitrogen or helium required, 2 Gauss line inside NMR device housing.
• Optional integrated online benchtop XRD such as Bruker D6 Phaser, Malvern Aeris, incl. XRD device, sample handover station, software and hardware integration