example solution
Flex

Automated small-scale / μL library synthesis

FLEX ISYNTH for microL library synthesis and reaction screening
Two blue chemspeed robotic platforms in metal sitting in a white hallway
Overview

Chemspeed's solution

Molecules discovery (e.g. in medicinal chemistry) is driven more and more by the demand for innovative medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same resources. 

Chemspeed’s fully automated, integrated FLEX ISYNTH wit SBS-plates based reaction format stands for a flexible, modular, and uncompromising automated solution that:

Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the reaction space, reagent space and molecule space.

Chemspeed’s ISYNTH deck modularity provides unrivalled versatility to execute and perform a variety of synthesis workflows (conventional, photochem, reactive gas) in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.

Enhances your efficiency and productivity by a factor of up to 100 in, for example: C-C / C-N coupling reactions, organometallic reactions (e.g. Grignard), alkylations, Diels-Alder reactions and transfer hydrogenations.


Workflow

Example workflow

FLEX ISYNTH - Library synthesis small scale

Benefits

Powerful advantages

  • Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid-phase and liquid-phase μL reaction screening.
  • Easy-to-use SBS-plate based disposable multi-functional, high-precision glass reactor arrays with μL reaction scale, screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C).
  • Work-up such as evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
  • Proprietary robotic tool exchange.
  • Gravimetric solid handling from μg to g.
  • Gravimetric liquid handling from mg to g / μL to mL.
  • Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
  • Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
  • Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
  • Ventilated hood for safety and conditioned operation.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
Software
Chemspeed AutoSuite Software laptop screen