FLEX ISYNTH for library synthesis and reaction screening with online/offline NMR
Automated, parallel library synthesis and reaction screening with online benchtop NMR (e.g. automated synthesis, online characterization, data analysis, AI / ML closed loop).
Molecules discovery (e.g. in medicinal chemistry) is driven more and more by the demand for innovative medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same resources.
Chemspeed’s fully automated, integrated FLEX ISYNTH stands for a flexible, modular, and uncompromising automated solution that:
Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the reaction space, reagent space and molecule space.
Chemspeed’s ISYNTH deck modularity provides unrivalled versatility to execute and perform a variety of synthesis workflows (conventional, MW-assisted, photochem, reactive gas) in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.
Enhances your efficiency and productivity by a factor of up to 100 in, for example: C-C / C-N coupling reactions, organometallic reactions (e.g. Grignard), alkylations, Diels-Alder reactions and transfer hydrogenations.
FLEX ISYNTH - Library synthesis with online NMR
- Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis as well as reaction screening.
- Easy-to-use disposable multi-functional, high-precision glass reactor arrays, available reaction scales from μL to mL.
- Glass reactor arrays with screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
- Proprietary robotic tool exchange.
- Gravimetric solid handling from μg to g.
- Gravimetric liquid handling from mg to g / μL to mL.
- Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
- Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
- Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
- Ventilated hood for safety and conditioned operation.
- AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
- Integrated online benchtop NMR - including but not limited to 80 MHz Fourier RxnLite, NMR device, sample injection port, software with advanced chemical profiling and hardware integration, H / F / C / P / Si / B, 1D and 2D spectra, online data acquisition via flow cell or offline via standard 5 mm sample tubes, permanent magnet - no liquid nitrogen or helium required, 2 Gauss line inside NMR device housing
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