Automated batch & flow chemistry

Each reactor with its own set of conditions - individually controlled tank reactors (reactor volumes 100, 240, 1’000 mL total volume) with precise, continuous feeds:

• Up to 12 / 24 experiments per run on an AUTOPLANT, up to 6 per run on a semi-automated MULTIPLANT.
• Unrivaled combination of batch & flow chemistry.
• Independent, precise process parameter control in each reactor (such as feed / flow, temperature, mixing).
• Independent gas, liquefied gas and liquid feeds.
• Gravimetric solid and (viscous) liquid dispensing.
• 4-Needle Head for volumetric liquid handling and sampling.
• PAT like IR, PSD, calorimetry, pH.
• Feeding and sampling under reaction conditions.
• Reaction under reflux at ambient pressure with optional Dean Stark water removal or distillation.
• Reactions at elevated pressure.
• Vessel-to-vessel transfer for multistep reactions.
• Workup with liquid / liquid extraction, drying, solid-phase extraction, filtration or evaporation.
• Cleaning in place (e.g. automated cleaning, inserts).
• Ventilated hood for safety and conditioned (sensitive chemicals, low-temperature) operation.
• AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
• Optional integrated online benchtop NMR with available operating frequency ranges of e.g. 80 / 90 MHz such as Bruker Fourier Rxn Lite, Magritek Spinsolve, incl. NMR device, sample injection port, software and hardware integration, H / F / C / P / Si / B, 1D and 2D spectra, online data acquisition via flow cell or offline via standard 5 mm sample tubes, permanent magnet - no liquid nitrogen or helium required, 2 Gauss line inside NMR device housing.