example solution
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Peptide, oligonucleotide and oligosaccharide synthesis

ISYNTH PSW for peptide and nucleotide synthesis
Overview

Chemspeed's solution

Molecules discovery (e.g. in medicinal chemistry) is driven more and more by the demand for innovative medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same resources. 

Chemspeed’s fully automated, integrated ISYNTH PSW stands for a flexible, modular, and uncompromising, innovative solution for automated, parallel synthesis of (oligo)peptide, (oligo)nucleotide and (oligo)saccharide libraries, work up and analysis that:

Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the reaction space, reagent space or molecule space.

Chemspeed’s ISYNTH deck modularity provides unrivalled versatility to execute and perform a variety of synthesis workflows (conventional, MW-assisted, photochem, reactive gas) in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.


Workflow

Example workflow

ISYNTH PSW

Benefits

Powerful advantages

  • Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis.
  • Easy-to-use disposable multi-functional, high-precision glass reactor arrays, available reaction scales from μL to mL.
  • Glass reactor arrays with screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C / -70°C), refluxing, vacuum, inertization, evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
  • Proprietary robotic tool exchange.
  • Gravimetric solid handling from μg to g.
  • Gravimetric liquid handling from mg to g / μL to mL.
  • Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
  • Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
  • Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry (optional integration within customized MBraun glove-box).
  • Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
Software
Chemspeed AutoSuite Software laptop screen