Accelerated, standardized crystallization screening

SWING CRYSTAL

Crystallization, polymorph, salt and solubility screening in unique MTP blocks with bottom glass-plate for direct transfer to XRPD.

Two blue chemspeed robotic platforms in metal sitting in a white hallway

Overview

Chemspeed's solution

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with a wide range of MTP-format crystallization plates and our user-friendly software enable you to accelerate, standardize, digitize your crystallization / polymorph screening.

Workflow

Example workflows

The interactive workflow panel below showcases example workflows for this solution. Each Chemspeed tool or module performs a set of specific actions, as in any manual lab workflow, and an almost limitless arrangement of these tools is possible.

SWING CRYSTAL - Crystallization screening

SWING CRYSTAL - Cooling (crash or controlled)

SWING CRYSTAL - Anti-solvent

SWING CRYSTAL - Evaporation (fast or slow)

SWING CRYSTAL - Slurry

Benefits

Powerful advantages

Decrease in cost per sample up to 90+ %.
Increase in productivity by a factor of 10.
Up to 192 crystallization experiments per run can be done on MTP based and other formats.
Wide range of workflows: salt, polymorph, co-crystal, solubility screening (incl. agitation, pH, temperature gradients, filtration, controlled evaporation).
Systematically investigate the influence of critical factors such as different solvents (eluotropic series), different concentrations, rate of evaporation, temperature, cooling rate, agitation on crystal structures.
Run two different crystallization workflows simultaneously.
Highly reliable and precise gravimetric dispensing tools for liquid and solid dispensing.
Different reactor / well sizes (from < 1 mL to 100 mL in disposable formats and up to 1’000 mL in high output process development reactors) allow for screening and development / scale-up on the same platform.
Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
Interface to DoE, ML, AI, LIMS, ERP.

Software

AUTOSUITE

Chemspeed’s AUTOSUITE software packages execute and control all modules in every solution. They control all Chemspeed robotic platforms and any other integrated 3^rd-party software and hardware.

Explore AUTOSUITE

Chemspeed AutoSuite Software laptop screen