Asymmetric hydrogenation of olefins with transition metal-based catalysts: practical insights from screening to production of APIs

Selective hydrogenation plays a critical role in modern synthetic chemistry, particularly in the pharmaceutical industry, where the production of chiral molecules with high enantiomeric purity is essential for the efficacy and safety of active pharmaceutical ingredients (APIs). By enabling the selective introduction of stereogenic centers, metal catalyzed hydrogenation processes are often the key to achieving the desired pharmacological properties. This article reviews both the historical evolution and modern strategies for developing enantioselective hydrogenation processes, focusing on a real case study where process optimization has been extensively studied to meet industrial requirements.

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Asymmetric hydrogenation of olefins with transition metal-based catalysts: practical insights from screening to production of APIs

MATTEO BAUDINO 1, LORENZO PONTINI 1, CHIARA PORTOLANI 1, GABRIELE PRINA CERAI 1, JACOPO ROLETTO 2

1. R&D researcher, Procos S.P.A., Cameri, Italy 
2. R&D director, Procos S.P.A., Cameri, Italy

https://www.procos.it/wp-content/uploads/2025/07/Asymmetric-hydrogenation-of-olefins-with-transition-metal-based-catalysts.pdf

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