Design and Implementation of a High-Throughput Experimentation Platform to Accelerate Drug Discovery

ACS Publications

Herein, we describe the development of the high-throughput experimentation platform and function in AbbVie’s Discovery Chemistry organization. The strategy and approach tailored specifically to medicinal chemistry needs are discussed. Additionally, we disclose the top reaction conditions for the most requested transformations obtained by analysis of the combined data set generated by the platform over five years.

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Design and Implementation of a High-Throughput Experimentation Platform to Accelerate Drug Discovery

Amanda W. Dombrowski, Ana L. Aguirre, and Ying Wang

AbbVie, Inc., North Chicago, Illinois 60064, United States

ACS Publications
https://doi.org/10.1021/acs.jmedchem.5c00814

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