Microparticles decorated with cell-instructive surface chemistries actively promote wound healing

Advanced Materials Journal

Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involved in the formation of granulation tissue, essential for effective wound healing. 315 different polymer surfaces are screened to identify candidates which actively drive fibroblasts toward either pro- or antiproliferative functional phenotypes. Fibroblast-instructive chemistries are identified, which are synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro-proliferative microfluidic derived particles are able to successfully promote neovascularization, granulation tissue formation, and wound closure after a single application to the wound bed. These active novel bio-instructive microparticles show great potential as a route to reducing the burden of chronic wounds.

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Microparticles decorated with cell-instructive surface chemistries actively promote wound healing

School of Life Sciences, University of Nottingham, Nottingham NG7 2RD, UK
A. Latif, L. E. Fisher, K. Lawler, A. M. Ghaemmaghami

Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK 
A. A. Dundas, V. Cuzzucoli Crucitti, R. Wildman, D. J. Irvine

School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK
Z. Imir, F. Pappalardo, M. R. Alexander

Commonwealth Scientific & Industrial Research Organization Canberra ACT 2601, Australia
B. W. Muir

Advanced Materials Journal
https://doi.org/10.1002/adma.202208364

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